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Phys. Chem. Chem. Phys., 2023,25, 13164-13169 SPICY : a method for single scan rotating frame relaxometry |
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| Author: | Tolkkinen, Katja1; Mailhiot, Sarah E.1; Selent, Anne1; |
| Organizations: |
1NMR Research Unit, University of Oulu, Oulu, Finland 2Department of Medicinal Chemistry, Uppsala University, Uppsala, Sweden 3Research Unit of Health Sciences and Technology, University of Oulu, Oulu, Finland
4Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland
5Medical Research Center Oulu, University of Oulu and Oulu University Hospital, Oulu, Finland |
| Format: | article |
| Version: | published version |
| Access: | open |
| Online Access: | PDF Full Text (PDF, 0.8 MB) |
| Persistent link: | http://urn.fi/urn:nbn:fi-fe2023051243675 |
| Language: | English |
| Published: |
Royal Society of Chemistry,
2023
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| Publish Date: | 2023-05-12 |
| Description: |
AbstractT1ρ is an NMR relaxation mode that is sensitive to low frequency molecular motions, making it an especially valuable tool in biomolecular research. Here, we introduce a new method, SPICY, for measuring T1ρ relaxation times. In contrast to conventional T1ρ experiments, in which the sequence is repeated many times to determine the T1ρ time, the SPICY sequence allows determination of T1ρ within a single scan, shortening the experiment time remarkably. We demonstrate the method using ¹H T1ρ relaxation dispersion experiments. Additionally, we combine the sequence with spatial encoding to produce 1D images in a single scan. We show that T1ρ relaxation times obtained using the single scan approach are in good agreement with those obtained using the traditional experiments. see all
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| Series: |
PCCP. Physical chemistry chemical physics |
| ISSN: | 1463-9076 |
| ISSN-E: | 1463-9084 |
| ISSN-L: | 1463-9076 |
| Volume: | 25 |
| Issue: | 18 |
| Pages: | 13164 - 13169 |
| DOI: | 10.1039/D2CP05988F |
| OADOI: | https://oadoi.org/10.1039/D2CP05988F |
| Type of Publication: |
A1 Journal article – refereed |
| Field of Science: |
114 Physical sciences 217 Medical engineering |
| Subjects: | |
| Funding: |
The authors acknowledge the financial support from the European Research Council (grant number 772110), the Academy of Finland (grant numbers 340099, 340761 and 896824), the Marie Sklodowska-Curie Actions (grant number 896824), KAUTE foundation and the University of Oulu Kvantum Institute. Part of this work was carried out with the support from the Centre for Material Analysis, the University of Oulu, Finland. |
| EU Grant Number: |
(772110) UFLNMR - Ultrafast Laplace NMR (896824) NMRCement - Zero-CO2 cement concept evaluated with novel Nuclear Magnetic Resonance (NMR) |
| Academy of Finland Grant Number: |
340099 340761 |
| Detailed Information: |
340099 (Academy of Finland Funding decision) 340761 (Academy of Finland Funding decision) |
| Copyright information: |
This journal is © the Owner Societies 2023. Open Access Article. Published on 13 April 2023. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. |
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https://creativecommons.org/licenses/by/3.0/ |