University of Oulu

Phys. Chem. Chem. Phys., 2023,25, 13164-13169

SPICY : a method for single scan rotating frame relaxometry

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Author: Tolkkinen, Katja1; Mailhiot, Sarah E.1; Selent, Anne1;
Organizations: 1NMR Research Unit, University of Oulu, Oulu, Finland
2Department of Medicinal Chemistry, Uppsala University, Uppsala, Sweden
3Research Unit of Health Sciences and Technology, University of Oulu, Oulu, Finland
4Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland
5Medical Research Center Oulu, University of Oulu and Oulu University Hospital, Oulu, Finland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 0.8 MB)
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Language: English
Published: Royal Society of Chemistry, 2023
Publish Date: 2023-05-12


T is an NMR relaxation mode that is sensitive to low frequency molecular motions, making it an especially valuable tool in biomolecular research. Here, we introduce a new method, SPICY, for measuring T relaxation times. In contrast to conventional T experiments, in which the sequence is repeated many times to determine the T time, the SPICY sequence allows determination of T within a single scan, shortening the experiment time remarkably. We demonstrate the method using ¹H T relaxation dispersion experiments. Additionally, we combine the sequence with spatial encoding to produce 1D images in a single scan. We show that T relaxation times obtained using the single scan approach are in good agreement with those obtained using the traditional experiments.

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Series: PCCP. Physical chemistry chemical physics
ISSN: 1463-9076
ISSN-E: 1463-9084
ISSN-L: 1463-9076
Volume: 25
Issue: 18
Pages: 13164 - 13169
DOI: 10.1039/D2CP05988F
Type of Publication: A1 Journal article – refereed
Field of Science: 114 Physical sciences
217 Medical engineering
Funding: The authors acknowledge the financial support from the European Research Council (grant number 772110), the Academy of Finland (grant numbers 340099, 340761 and 896824), the Marie Sklodowska-Curie Actions (grant number 896824), KAUTE foundation and the University of Oulu Kvantum Institute. Part of this work was carried out with the support from the Centre for Material Analysis, the University of Oulu, Finland.
EU Grant Number: (772110) UFLNMR - Ultrafast Laplace NMR
(896824) NMRCement - Zero-CO2 cement concept evaluated with novel Nuclear Magnetic Resonance (NMR)
Academy of Finland Grant Number: 340099
Detailed Information: 340099 (Academy of Finland Funding decision)
340761 (Academy of Finland Funding decision)
Copyright information: This journal is © the Owner Societies 2023. Open Access Article. Published on 13 April 2023. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.