Piñeiro-Ramos, J.D.; Rahkonen, O.; Korpioja, V.; Quintás, G.; Pihkala, J.; Pitkänen-Argillander, O.; Rautiainen, P.; Andersson, S.; Kuligowski, J.; Vento, M. A Reductive Metabolic Switch Protects Infants with Transposition of Great Arteries Undergoing Atrial Septostomy against Oxidative Stress. Antioxidants 2021, 10, 1502. https://doi.org/10.3390/antiox10101502
A reductive metabolic switch protects infants with transposition of great arteries undergoing atrial septostomy against oxidative stress
|Author:||Piñeiro-Ramos, José David1; Rahkonen, Otto2; Korpioja, Virpi3;|
1Neonatal Research Unit, Health Research Institute Hospital La Fe, Avenida Fernando Abril Martorell 106, 46026 Valencia, Spain
2Department of Paediatric Cardiology, New Children’s Hospital, University of Helsinki and Helsinki University Hospital, Box 347, Stenbäckinkatu 9, 00029 Helsinki, HUS, Finland
3Department of Children and Adolescents, Oulu University Hospital, P.O. Box 23, FIN-90029 OYS, 90570 Oulu, Finland
4Health & Biomedicine Unit, Leitat Technological Center, Par Cientific Barcelona, 08028 Barcelona, Spain
5Analytical Unit, Health Research Institute La Fe, Avenida, Fernando Abril Martorell 106, 46026 Valencia, Spain
6Department of Paediatric Cardiology, New Children’s Hospital, University of Helsinki and Helsinki University Hospital, Box 347, Stenbäckinkatu 9, 00029, Helsinki, HUS, Finland
7Department of Anaesthesia and Intensive Care, New Children’s Hospital, Helsinki University Hospital and University of Helsinki, Stenbackinkatu 9, 00029 Helsinki, Finland
8Pediatric Research Center, New Children’s Hospital, Helsinki University Hospital and University of Helsinki, Stenbackinkatu 9, 00029 Helsinki, Finland
9Division of Neonatology, University & Polytechnic Hospital La Fe, Avenida Fernando Abril Martorell 106, 46026 Valencia, Spain
|Online Access:||PDF Full Text (PDF, 1.7 MB)|
|Persistent link:|| http://urn.fi/urn:nbn:fi-fe2023051243727
Multidisciplinary Digital Publishing Institute,
|Publish Date:|| 2023-05-12
Transposition of the great arteries (TGA) is one of the most common cyanotic congenital heart diseases requiring neonatal surgical intervention. Parallel circulations that result in impaired cerebral oxygen delivery already in utero may lead to brain damage and long-term neurodevelopmental delay. Balloon atrial septostomy (BAS) is often employed to mix deoxygenated and oxygenated blood at the atrial level. However, BAS causes a sudden increase in arterial blood oxygenation and oxidative stress. We studied changes in oxygen saturation as well as metabolic profiles of plasma samples from nine newborn infants suffering from TGA before and until 48 h after undergoing BAS. The plasma metabolome clearly changed over time and alterations of four metabolic pathways, including the pentose phosphate pathway, were linked to changes in the cerebral tissue oxygen extraction. In contrast, no changes in levels of lipid peroxidation biomarkers over time were observed. These observations suggest that metabolic adaptations buffer the free radical burst triggered by re-oxygenation, thereby avoiding structural damage at the macromolecular level. This study enhances our understanding of the complex response of infants with TGA to changes in oxygenation induced by BAS.
|Type of Publication:||
A1 Journal article – refereed
|Field of Science:||
3123 Gynaecology and paediatrics
3121 General medicine, internal medicine and other clinical medicine
This research was funded by Instituto de Salud Carlos III [CP16/00034, PI17/00127, and PI20/00964], the RETICS funded by the PN 2018–2021 (Spain), ISCIII-Sub-Directorate General for Research Assessment and Promotion and the European Regional Development Fund (FEDER) [RD16/0022]; and the Foundation for Pediatric Research in Finland and Special Governmental Subsidy for Clinical Research.
Metabolomics data are available on Zenodo (https://zenodo.org/record/4495124#.YBpwoC1DkWp (2 February 2021)).
© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).