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Akhi, R., Nissinen, A. E., Wang, C., Kyrklund, M., Paju, S., Mäntylä, P., Buhlin, K., Sinisalo, J., Pussinen, P. J., & Hörkkö, S. Salivary IgA antibody to malondialdehyde–acetaldehyde associates with mild periodontal pocket depth. Oral Diseases. 2022;28:2285–2293. https://doi.org/10.1111/odi.13936

Salivary IgA antibody to malondialdehyde–acetaldehyde associates with mild periodontal pocket depth

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Author: Akhi, Ramin1,2; Nissinen, Antti E.1,2; Wang, Chunguang1,2;
Organizations: 1Medical Microbiology and Immunology, Research Unit of Biomedicine, University of Oulu, Oulu, Finland
2Medical Research Center, Oulu University Hospital and University of Oulu, Oulu, Finland
3Oral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
4Institute of Dentistry, University of Eastern Finland, Kuopio, Finland
5Division of Periodontology, Department of Dental Medicine, Karolinska Institutet, Huddinge, Sweden
6HUCH Heart and Lung Center, Helsinki University Hospital, Helsinki, Finland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 0.5 MB)
Persistent link: http://urn.fi/urn:nbn:fi-fe2023051243948
Language: English
Published: John Wiley & Sons, 2022
Publish Date: 2023-05-12
Description:

Abstract

Objective: Oxidized epitopes such as malondialdehyde–acetaldehyde (MAA) play a crucial role in the progression of atherosclerosis through activation of the humoral immune response. The exact mechanism of the association between atherosclerosis and periodontal diseases is not fully understood. The aim of the current study is to evaluate the association of oral humoral immune response to oxidized epitopes with parameters of periodontal disease.

Materials and methods: The Parogene cohort consist of patients who have undergone coronary angiography due to cardiac symptoms. In this study, 423 patients were randomly selected for an extensive oral examination. Salivary Immunoglobulin A to oxidized epitopes and bacterial antigens was determined by chemiluminescence immunoassay.

Results: In a binary logistic regression model adjusted with periodontal disease confounders, periodontal pocket depth (PPD) 4–5 mm associated with salivary IgA antibodies to MAA-LDL (p = 0.034), heat shock protein 60 of Aggregatibacter actinomycetemcomitans (p = 0.045), Porphyromonas gingivalis (p = 0.045), A. actinomycetemcomitans (p = 0.005), P. intermedia (p = 0.020), and total IgA (p = 0.003).

Conclusions: The current study shows the association of salivary IgA to MAA-LDL with PPD 4–5 mm in a cohort of patients with chronic coronary artery disease. Humoral immune cross-reactivation to oxidized epitopes such MAA-LDL could partly explain the link of periodontitis with systemic diseases.

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Series: Oral diseases
ISSN: 1354-523X
ISSN-E: 1601-0825
ISSN-L: 1354-523X
Volume: 28
Issue: 8
Pages: 2258 - 2293
DOI: 10.1111/odi.13936
OADOI: https://oadoi.org/10.1111/odi.13936
Type of Publication: A1 Journal article – refereed
Field of Science: 313 Dentistry
Subjects:
IgA
MAA
malondialdehyde-acetaldehyde
periodontal pocket depth
periodontitis
Article
Funding: University of Oulu Scholarship Foundation; The Paulo foundation; University of Oulu Graduate School; Finnish Dental Society Apollonia; The Päivikki and Sakari Sohlberg foundation; The Sigrid Juselius foundation; Academy of Finland, Grant/Award Number: 1266953.
Dataset Reference: Research data not shared.
Copyright information: © 2021 The Authors. Oral Diseases published by Wiley Periodicals LLC. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
  https://creativecommons.org/licenses/by-nc/4.0/