University of Oulu

Seyedamirhosein Abdorahimzadeh, Feby W. Pratiwi, Seppo J. Vainio, Henrikki Liimatainen, Caglar Elbuken, Interplay of electric field and pressure-driven flow inducing microfluidic particle migration, Chemical Engineering Science, Volume 276, 2023, 118754, ISSN 0009-2509,

Interplay of electric field and pressure-driven flow inducing microfluidic particle migration

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Author: Abdorahimzadeh, Seyedamirhosein1; Pratiwi, Feby W.1; Vainio, Seppo J.1;
Organizations: 1Disease Networks Research Unit, Faculty of Biochemistry and Molecular Medicine, University of Oulu, P. O. Box 5400, FI-90014 Oulu, Finland
2Fiber and Particle Engineering Research Unit, Faculty of Technology, University of Oulu, P. O. Box 4300, FI-90014 Oulu, Finland
3Biomedicine Research Unit, Faculty of Medicine, University of Oulu, P. O. Box 5000, FI-90014 Oulu, Finland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 3.6 MB)
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Language: English
Published: Elsevier, 2023
Publish Date: 2023-05-23


The lateral migration of colloidal particles inside a microfluidic channel has gained attention due to being both fundamentally intriguing and applicable for particle separation, such as cancer cell isolation or extracellular vesicle purification. Applying an external electric field combined with a pressure-driven flow induces such lateral migrations. In this study, new modes of lateral particle migration have been found by experimentally investigating 6 µm particles in the co-presence of electric field and pressure-driven flow. The experiments revealed the importance of the relative strengths of electric field and pressure gradient in determining particle lateral positioning. We hypothesize that the nonuniformity of the polarization caused by the external electric field and the rotation of the particle due to the background pressure-driven flow result in these modes of transverse migration. These new migration patterns are further utilized to perform microparticle separation and, more importantly, present a novel separation modality.

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Series: Chemical engineering science
ISSN: 0009-2509
ISSN-E: 1873-4405
ISSN-L: 0009-2509
Volume: 276
Article number: 118754
DOI: 10.1016/j.ces.2023.118754
Type of Publication: A1 Journal article – refereed
Field of Science: 215 Chemical engineering
Funding: This work was supported by the Kvantum Institute project BioEVEngine (University of Oulu), Finland.
Copyright information: © 2023 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (