University of Oulu

Lumme J, Morin-Papunen L, Pesonen P, Sebert S, Hyppönen E, Järvelin M-R, Herzig K-H, Ojaniemi M, Niinimäki M. Vitamin D Status in Women with a History of Infertility and Decreased Fecundability: A Population-Based Study. Nutrients. 2023; 15(11):2522.

Vitamin D status in women with a history of infertility and decreased fecundability : a population-based study

Saved in:
Author: Lumme, Johanna1,2,3; Morin-Papunen, Laure1,2,3; Pesonen, Paula4;
Organizations: 1Research Unit of Clinical Medicine, University of Oulu, 90014 Oulu, Finland
2Medical Research Center, Oulu University Hospital and University of Oulu, 90220 Oulu, Finland
3Department of Obstetrics and Gynecology, Oulu University Hospital, Wellbeing Services County of North Ostrobothnia, 90220 Oulu, Finland
4Northern Finland Birth Cohort, Infrastructure for Population Studies, Faculty of Medicine, University of Oulu, 90014 Oulu, Finland
5Research Unit of Population Health, University of Oulu, 90014 Oulu, Finland
6Australian Centre for Precision Health, Cancer Research Institute, University of South Australia, Adelaide 5000, Australia
7Unit of Clinical and Health Sciences, University of South Australia, Adelaide 5000, Australia
8South Australian Health and Medical Research Institute, Adelaide 5000, Australia
9Department of Epidemiology and Biostatistics, MRC Centre for Environment and Health, School of Public Health, Imperial College, London W2 1PG, UK
10Department of Life Sciences, College of Health and Life Sciences, Brunel University London Kingston Lane, Uxbridge UB8 3PH, UK
11Unit of Primary Care, Oulu University Hospital, Wellbeing Services County of North Ostrobothnia, 90220 Oulu, Finland
12Research Unit of Biomedicine and Internal Medicine, University of Oulu, 90014 Oulu, Finland
13Department of Gastroenterology and Metabolism, Poznan University of Medical Sciences, 61-701 Poznan, Poland
14Department of Pediatrics and Adolescence, Oulu University Hospital, Wellbeing Services County of North Ostrobothnia, 90220 Oulu, Finland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 0.9 MB)
Persistent link:
Language: English
Published: Multidisciplinary Digital Publishing Institute, 2023
Publish Date: 2023-05-31


Background: Infertility and fecundability problems have been linked with lower 25-hydroxyvitamin D (25(OH)D) concentrations, but studies conducted with small, heterogenous or selected populations have shown inconsistent results.

Methods: This study included women at age 31 from prospective population-based Northern Finland Birth Cohort 1966. Serum 25(OH)D concentrations were evaluated between women with or without previous infertility examinations or treatments (infertility group, n = 375, reference group, n = 2051) and time to pregnancy (TTP) of over 12 months (decreased fecundability group, n = 338) with a wide range of confounders. Furthermore, 25(OH)D concentrations were also compared among reproductive outcomes.

Results: The mean 25(OH)D concentration was lower and 25(OH)D < 30 nmol/L was more frequent in women with a history of infertility compared to reference group. Moreover, 25(OH)D > 75 nmol/L was more frequent in the reference group. The mean 25(OH)D concentration was lower in women who had had multiple miscarriages. Both history of infertility (β = −2.7, 95% confidence interval (CI) −4.6, −0.7) and decreased fecundability associated with lower 25(OH)D concentration (β = −4.1, 95% CI −7.4, −0.8) after adjustments. In conclusion, this population-based study demonstrated that previous infertility and decreased fecundability were associated with lower 25(OH)D.

see all

Series: Nutrients
ISSN: 2072-6643
ISSN-E: 2072-6643
ISSN-L: 2072-6643
Volume: 15
Issue: 11
Article number: 2522
DOI: 10.3390/nu15112522
Type of Publication: A1 Journal article – refereed
Field of Science: 3123 Gynaecology and paediatrics
Funding: Johanna Lumme: Päivikki and Sakari Sohlberg Foundation, the Health and Biosciences Doctoral Programme, HBS-DP (UniOGS, University of Oulu) and the Scholarship Fund of the University of Oulu. Maarit Niinimäki, Marja Ojaniemi: University Hospital of Oulu and PEDEGO Research Unit, University of Oulu Research Funds. Karl-Heinz Herzig: H2020-633595 Dynahealth. Sylvain Sebert, Marjo-Riitta Järvelin: H2020-733206 LifeCycle. Marjo-Riitta Järvelin: Academy of Finland grant numbers 24300796, 24302031, 285547 (EGEA); H2020-643774 iHealth-T2D, H2020-825762 EDCMET and Medical Research Council Biotechnology and Biological Sciences Research Council PREcisE (Nutrition and Epigenome), The Joint Programming Initiative a Healthy Diet for a Healthy Life (JPI HDHL/EU-H2020).
EU Grant Number: (633595) DYNAHEALTH - Understanding the dynamic determinants of glucose homeostasis and social capability to promote Healthy and active aging
(733206) LIFECYCLE - Early-life stressors and LifeCycle health
(643774) iHealth-T2D - Family-based intervention to improve healthy lifestyle and prevent Type 2 Diabetes amongst South Asians with central obesity and prediabetes
(825762) EDCMET - Metabolic effects of Endocrine Disrupting Chemicals: novel testing METhods and adverse outcome pathways
Academy of Finland Grant Number: 285547
Detailed Information: 285547 (Academy of Finland Funding decision)
Copyright information: © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (