University of Oulu

Kamakura, R., Raza, G. S., Sodum, N., Lehto, V.-P., Kovalainen, M., Herzig, K.-H., Colonic Delivery of Nutrients for Sustained and Prolonged Release of Gut Peptides: A Novel Strategy for Appetite Management. Mol. Nutr. Food Res. 2022, 66, 2200192.

Colonic delivery of nutrients for sustained and prolonged release of gut peptides : a novel strategy for appetite management

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Author: Kamakura, Remi1; Raza, Ghulam Shere1; Sodum, Nalini1;
Organizations: 1Research Unit of Biomedicine, Faculty of Medicine, and Medical Research Center, University of Oulu and Oulu University Hospital, Oulu, 90220 Finland
2Department of Applied Physics, Faculty of Science and Forestry, University of Eastern Finland, Kuopio, FI-70211 Finland
3Department of Pediatric Gastroenterology and Metabolic Diseases, Pediatric Institute, Poznan University of Medical Sciences, Poznań, 60–572 Poland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 1.1 MB)
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Language: English
Published: John Wiley & Sons, 2022
Publish Date: 2023-05-31


Obesity is one of the major global threats to human health and risk factors for cardiometabolic diseases and certain cancers. Glucagon-like peptide-1 (GLP-1) plays a major role in appetite and glucose homeostasis and recently the USFDA approved GLP-1 agonists for the treatment of obesity and type 2 diabetes. GLP-1 is secreted from enteroendocrine L-cells in the distal part of the gastrointestinal (GI) tract in response to nutrient ingestion. Endogenously released GLP-1 has a very short half-life of <2 min and most of the nutrients are absorbed before reaching the distal GI tract and colon, which hinders the use of nutritional compounds for appetite regulation. The review article focuses on nutrients that endogenously stimulate GLP-1 and peptide YY (PYY) secretion via their receptors in order to decrease appetite as preventive action. In addition, various delivery technologies such as pH-sensitive, mucoadhesive, time-dependent, and enzyme-sensitive systems for colonic targeting of nutrients delivery are described. Sustained colonic delivery of nutritional compounds could be one of the most promising approaches to prevent obesity and associated metabolic diseases by, e.g., sustained GLP-1 release.

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Series: Molecular nutrition & food research
ISSN: 1613-4125
ISSN-E: 1613-4133
ISSN-L: 1613-4125
Volume: 66
Issue: 19
Article number: e2200192
DOI: 10.1002/mnfr.202200192
Type of Publication: A2 Review article in a scientific journal
Field of Science: 3111 Biomedicine
Funding: The financial support from Finnish Cultural Foundation and Orion Research Foundation (RK) are greatly acknowledged.
Copyright information: © 2022 The Authors. Molecular Nutrition & Food Research published by Wiley-VCH GmbH. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.