Wirkkala, J., Kubin, A.-M., Ohtonen, P., Falck, A., & Hautala, N. (2023). Outcomes of 35-year duration of type 1 diabetes and proliferative diabetic retinopathy on functional vision and quality of life: Benefits of good glycemic control. Journal of Diabetes and Its Complications, 37(2), 108408. https://doi.org/10.1016/j.jdiacomp.2023.108408
Outcomes of 35-year duration of type 1 diabetes and proliferative diabetic retinopathy on functional vision and quality of life : benefits of good glycemic control
|Author:||Wirkkala, Joonas1,2; Kubin, Anna-Maria1,2; Ohtonen, Pasi3,4;|
1Department of Ophthalmology, Research Unit of Clinical Medicine and Medical Research Centre, University of Oulu, Finland
2Oulu University Hospital, Oulu, Finland
3Research Service Unit, Oulu, Finland
4The Research Unit of Surgery, Anaesthesia and Intensive Care, Oulu University Hospital and University of Oulu, Oulu, Finland
|Persistent link:|| http://urn.fi/urn:nbn:fi-fe2023060252047
|Publish Date:|| 2024-01-26
Aims: To evaluate clinical outcomes, functional vision and quality of life (QoL) after 35-year duration of type 1 diabetes (T1D) and proliferative diabetic retinopathy (PDR).
Methods: A population-based cohort study of T1D. Data from laboratory tests, ophthalmic examinations, multifunctional vision-test, and 15D-QoL measurements were analysed.
Results: 35 % of the original cohort (n = 216) had PDR, and 48 % of them were re-evaluated. They were 41 ± 3 [34–46] years old and 62 % were males. The duration of T1D was 35 ± 4 [29–41] years. 76 % had transdermal glucose monitoring. HbA1c had decreased from 80.1 mmol/mol to 63.6 mmol/mol (p < 0.001). Visual acuity was 73–77 ETDRS-letters. Two patients had visual impairment. Visual field sensitivities were lower in PDR vs. healthy controls (23.2 ± 3.9 dB vs. 26.9 ± 1.0 dB, and 14.9 ± 5.6 dB vs. 21.0 ± 2.0 dB, respectively, p < 0.001). Contrast sensitivity was similar, but the reaction time was longer in the PDR group (490.5 ms vs. 462.8 ms, p = 0.004). QoL-parameters concerning sleeping, usual activities, discomfort and symptoms, and sexual activity had decreased, but improved for mobility and distress.
Conclusions: Long-term visual prognosis and QoL remained good despite the declined functional vision caused by PDR.
Journal of diabetes and its complications
|Type of Publication:||
A1 Journal article – refereed
|Field of Science:||
3121 General medicine, internal medicine and other clinical medicine
© 2023. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http:/creativecommons.org/licenses/by-nc-nd/4.0/