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Association of renal function screening frequency with renal function decline in patients with type 2 diabetes : a real-world study in primary health care |
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| Author: | Sundqvist, Henry1,2; Heikkala, Eveliina1,2,3; Jokelainen, Jari2; |
| Organizations: |
1Rovaniemi Health Center, Koskikatu 25, 96200, Rovaniemi, Finland 2Center for Life Course Health Research, University of Oulu, P.O Box 8000, FI-90014, Oulu, Finland 3Medical Research Center Oulu, University of Oulu and Oulu University Hospital, P.O Box 5000, 90014, Oulu, Finland
4Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy
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| Format: | article |
| Version: | published version |
| Access: | open |
| Online Access: | PDF Full Text (PDF, 0.8 MB) |
| Persistent link: | http://urn.fi/urn:nbn:fi-fe2023060552502 |
| Language: | English |
| Published: |
Springer Nature,
2022
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| Publish Date: | 2023-06-05 |
| Description: |
AbstractAims: To examine the association of the screening frequency of estimated glomerular filtration rate (eGFR) with the substantial reduction in eGFR (≥ 25%) among type 2 diabetes (T2D) patients with normal (eGFR≥60 ml/min/1.73 m2) and impaired kidney function (eGFR < 60 ml/min/1.73 m2). Methods: A longitudinal study involving 5104 T2D patients with follow-up period of 6.8 years (1.9 SD) were treated at the Rovaniemi Health Center, Rovaniemi, Finland during 2011–2019. The association between the screening frequency of eGFR (yearly vs. non-yearly) and the substantial reduction in eGFR was studied with logistical models and adjusted with biochemical variables and preventive medications. Results: Among the T2D patients with normal kidney function, non-yearly eGFR screening was significantly associated with substantial eGFR reduction in both unadjusted (odds ratio [OR] 3.29, 95% confidence interval [CI] 2.54–4.33) and adjusted models (OR 2.06, 95% CI 1.21–3.73) compared with yearly screening frequency. In the group of patients with impaired kidney function in the unadjusted model, non-yearly eGFR screening was significantly associated with substantial eGFR reduction (OR 2.38, 95% CI 1.30–4.73), but became non-significant after adjustments (OR 1.89, 95% CI 0.61–7.21). Conclusions: This study underscores the role of regular eGFR screening in the prevention of kidney function decline. see all
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| Series: |
BMC nephrology |
| ISSN: | 1471-2369 |
| ISSN-E: | 1471-2369 |
| ISSN-L: | 1471-2369 |
| Volume: | 23 |
| Article number: | 356 |
| DOI: | 10.1186/s12882-022-02979-1 |
| OADOI: | https://oadoi.org/10.1186/s12882-022-02979-1 |
| Type of Publication: |
A1 Journal article – refereed |
| Field of Science: |
3121 General medicine, internal medicine and other clinical medicine |
| Subjects: | |
| Funding: |
This study has received funding from the Sakari Alhopuro Foundation. |
| Copyright information: |
© The Author(s) 2022. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
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https://creativecommons.org/licenses/by/4.0/ |