Sundqvist, H., Heikkala, E., Jokelainen, J. et al. Association of renal function screening frequency with renal function decline in patients with type 2 diabetes: a real-world study in primary health care. BMC Nephrol 23, 356 (2022). https://doi.org/10.1186/s12882-022-02979-1
Association of renal function screening frequency with renal function decline in patients with type 2 diabetes : a real-world study in primary health care
|Author:||Sundqvist, Henry1,2; Heikkala, Eveliina1,2,3; Jokelainen, Jari2;|
1Rovaniemi Health Center, Koskikatu 25, 96200, Rovaniemi, Finland
2Center for Life Course Health Research, University of Oulu, P.O Box 8000, FI-90014, Oulu, Finland
3Medical Research Center Oulu, University of Oulu and Oulu University Hospital, P.O Box 5000, 90014, Oulu, Finland
4Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy
|Online Access:||PDF Full Text (PDF, 0.8 MB)|
|Persistent link:|| http://urn.fi/urn:nbn:fi-fe2023060552502
|Publish Date:|| 2023-06-05
Aims: To examine the association of the screening frequency of estimated glomerular filtration rate (eGFR) with the substantial reduction in eGFR (≥ 25%) among type 2 diabetes (T2D) patients with normal (eGFR≥60 ml/min/1.73 m2) and impaired kidney function (eGFR < 60 ml/min/1.73 m2).
Methods: A longitudinal study involving 5104 T2D patients with follow-up period of 6.8 years (1.9 SD) were treated at the Rovaniemi Health Center, Rovaniemi, Finland during 2011–2019. The association between the screening frequency of eGFR (yearly vs. non-yearly) and the substantial reduction in eGFR was studied with logistical models and adjusted with biochemical variables and preventive medications.
Results: Among the T2D patients with normal kidney function, non-yearly eGFR screening was significantly associated with substantial eGFR reduction in both unadjusted (odds ratio [OR] 3.29, 95% confidence interval [CI] 2.54–4.33) and adjusted models (OR 2.06, 95% CI 1.21–3.73) compared with yearly screening frequency. In the group of patients with impaired kidney function in the unadjusted model, non-yearly eGFR screening was significantly associated with substantial eGFR reduction (OR 2.38, 95% CI 1.30–4.73), but became non-significant after adjustments (OR 1.89, 95% CI 0.61–7.21).
Conclusions: This study underscores the role of regular eGFR screening in the prevention of kidney function decline.
|Type of Publication:||
A1 Journal article – refereed
|Field of Science:||
3121 General medicine, internal medicine and other clinical medicine
This study has received funding from the Sakari Alhopuro Foundation.
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