University of Oulu

Junttola, Ulla; Lahtinen, Sanna; Isokangas, Juha-Matti; Hietanen, Siiri; Vakkala, Merja; Kaakinen, Timo and Liisanantti, Janne. “Long-Term Mortality after Endovascular Thrombectomy for Stroke.” Journal of Stroke and Cerebrovascular Diseases 31, no. 12 (December 2022): 106832.

Long-term mortality after endovascular thrombectomy for stroke

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Author: Junttola, Ulla1,2; Lahtinen, Sanna1,3; Isokangas, Juha-Matti1,4;
Organizations: 1Medical Research Center Oulu, Research Group of Surgery, Anesthesiology and Intensive Care, Finland
2Departments of Neurology, Oulu University Hospital, OYS, P.O.BOX 21, Oulu 90029, Finland
3Anesthesiology and Intensive Care, Oulu, Finland
4Radiology, Oulu, Finland
5Department of Internal Medicine and Cardiology, Central Ostrobothnian Central Hospital, Kokkola, Finland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 0.4 MB)
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Language: English
Published: Elsevier, 2022
Publish Date: 2023-06-05


Objectives: Endovascular thrombectomy (EVT) has become the standard treatment for large vessel occlusion (LVO) in acute ischemic stroke. Stroke trials typically report clinical outcome at the three-month time point but there is a lack of studies focusing on the long-term outcome after EVT. The aim of this study is to assess the long-term mortality after EVT for stroke and to determine the factors that are associated with mortality.

Methods: Retrospective single-center analysis of 323 patients who underwent EVT for stroke between the years 2015–2019 and survived at least 30 days. Patients were followed up until the end of the year 2020. Cox regression analysis was used to identify the factors associated with mortality.

Results: A total of 53 (16.4%) of the 30-day survivors died during the follow-up. According to the Cox regression analysis, mortality was associated with functional dependence (modified Rankin Scale (mRS) <2, HR 2.7 (95% CI 1.2–5.9), p=0.013), comorbidity (Charlson Comorbidity Index (CCI) ≥3, HR 2.7 (95% CI 1.4–5.5), p=0.004), stroke severity at baseline (National Institutes of Health Stroke Scale (NIHSS) <8, HR 1.9 (95% CI 1.1–3.3), p=0.026), and medical complications (HR 2.4 (95% CI 1.2–4.8), p=0.011). Procedural variables did not have an impact on mortality.

Conclusions: Functional dependence, stroke severity, comorbidity, and medical complications during the hospital stay were associated with the long-term mortality after EVT for stroke.

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Series: Journal of stroke and cerebrovascular diseases
ISSN: 1052-3057
ISSN-E: 1532-8511
ISSN-L: 1052-3057
Volume: 31
Issue: 12
Article number: 106832106832
DOI: 10.1016/j.jstrokecerebrovasdis.2022.106832
Type of Publication: A1 Journal article – refereed
Field of Science: 3126 Surgery, anesthesiology, intensive care, radiology
Copyright information: © 2022 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (