Mononen, M., Saari, E., Hasala, H., Kettunen, H.-P., Suoranta, S., Nurmi, H., Randell, J., Laurikka, J., Uibu, T., Koskela, H., Kaarteenaho, R., & Purokivi, M. (2022). Risk factors of clinically significant complications in transbronchial lung cryobiopsy: A prospective multi-center study. Respiratory Medicine, 200, 106922. https://doi.org/10.1016/j.rmed.2022.106922
Risk factors of clinically significant complications in transbronchial lung cryobiopsy : a prospective multi-center study
|Author:||Mononen, Minna1,2; Saari, Eeva1,2; Hasala, Hannele3;|
1Division of Respiratory Medicine, Institute of Clinical Medicine, School of Medicine, Faculty of Health Sciences, University of Eastern Finland, POB 1627, 70211, Kuopio, Finland
2Center of Medicine and Clinical Research, Division of Respiratory Medicine, Kuopio University Hospital, POB 100, 70029, Kuopio, Finland
3Department of Respiratory Medicine, Tampere University Hospital, POB 2000, 33521, Tampere, Finland
4Department of Clinical Radiology, Kuopio University Hospital, POB 100, 70029, Kuopio, Finland
5Institute of Clinical Radiology, School of Medicine, Faculty of Health Sciences, University of Eastern Finland, POB 1627, 70211, Kuopio, Finland
6Tampere University Heart Hospital, and Finnish Cardiovascular Research Center, Tampere University, FI-33014, Tampere, Finland
7Research Unit of Internal Medicine, University of Oulu and Medical Research Center Oulu, Oulu University Hospital, POB 20, 90029, Oulu, Finland
|Online Access:||PDF Full Text (PDF, 0.7 MB)|
|Persistent link:|| http://urn.fi/urn:nbn:fi-fe2023060552549
|Publish Date:|| 2023-06-05
Background: The use of a transbronchial lung cryobiopsy (TBLC) is increasing as a diagnostic method of interstitial lung diseases (ILD). This study aimed to evaluate risk factors associated with clinically significant complications of TBLC in ILD patients.
Methods: Patients referred to Kuopio or Tampere university hospitals, in Finland, for a suspected ILD were included. The TBLC was performed in an outpatient setting for 100 patients. Patients were mechanically ventilated in general anesthesia. Fluoroscopy guidance and prophylactic bronchial balloon were used. Complications, such as bleeding, pneumothorax, infections, and mortality were recorded. Moderate or serious bleeding, pneumothorax, or death ≤90 days were defined as clinically significant complications. A multivariable model was created to assess clinically significant complications.
Results: The extent of traction bronchiectasis (Odds ratio [OR] 1.30, Confidence interval [CI] 1.03–1.65, p = 0.027) and young age (OR 7.96, CI 2.32–27.3, p = 0.001) were associated with the risk of clinically significant complications whereas the use of oral corticosteroids ≤30 days before the TBLC (OR 3.65, CI 0.911–14.6, p = 0.068) did not quite reach statistical significance. A history of serious cough was associated with the risk of pneumothorax (OR 4.18, CI 1.10–16.0, p = 0.036). Procedure associated mortality ≤90 days was 1%.
Conclusions: The extent of traction bronchiectasis on HRCT and young age were associated with the risk of clinically significant complications whereas oral corticosteroid use did not quite reach statistical significance. A history of serious cough was associated with the risk of clinically significant pneumothorax.
|Type of Publication:||
A1 Journal article – refereed
|Field of Science:||
3121 General medicine, internal medicine and other clinical medicine
This study was supported by the Foundation of the Finnish Anti-Tuberculosis Association to MM, ES, and MP; Väinö and Laina Kivi Foundation to MM; Research Foundation of the Pulmonary Diseases to MM; Jalmari and Rauha Ahokas Foundation to MM, ES, and MP; and Respiratory Foundation of the Kuopio Region to ES and MP.
© 2022 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).