Pirhonen, E, Haapea, M, Rautio, N, et al. Characteristics and predictors of off-label use of antipsychotics in general population sample. Acta Psychiatr Scand. 2022; 146( 3): 227- 239. doi:10.1111/acps.13472
Characteristics and predictors of off-label use of antipsychotics in general population sample
|Author:||Pirhonen, Eero1; Haapea, Marianne1,2,3; Rautio, Nina1,2;|
1Center for Life Course Health Research, University of Oulu, Oulu, Finland
2Research Unit of Biomedicine, Medical Research Center Oulu and Oulu University Hospital, University of Oulu, Oulu, Finland
3Department of Psychiatry, Oulu University Hospital, Oulu, Finland
4Northern Finland Birth Cohorts, Arctic Biobank, Infrastructure for Population Studies, University of Oulu, Oulu, Finland
5Helsinki University Hospital, Psychiatry, University of Helsinki, Helsinki, Finland
|Online Access:||PDF Full Text (PDF, 1.4 MB)|
|Persistent link:|| http://urn.fi/urn:nbn:fi-fe2023060552557
John Wiley & Sons,
|Publish Date:|| 2023-06-05
Objective: Increasing number of people have been prescribed antipsychotics (APs) off-label in recent decades. This study aimed to identify the characteristics and predictors of receiving prescription of antipsychotics off-label.
Methods: The study sample was part of the Northern Finland Birth Cohort 1966 (n = 7071). Data included questionnaires and national register data. Information on prescribed medications was extracted from the national register. The sample was divided into three groups: Persons who had been prescribed APs off-label (n = 137), individuals with non-psychotic mental disorders without APs off label (n = 1478) and individuals who had been diagnosed with psychosis or bipolar disorder and who had been prescribed APs (n = 151). We compared sociodemographic, lifestyle and clinical characteristics between the off-label and the comparison groups using logistic regression.
Results: The most common diagnoses in the off-label group were depression (n = 96, 70.1%) and anxiety (n = 55, 40.1%). Compared with individuals with non-psychotic mental disorders who were not prescribed APs off-label, individuals with prescribed off-label APs had a lower level of education, lower socioeconomic status, were less often married, had a higher level of somatic and psychiatric morbidity, were more often smokers and more often had a substance abuse disorder and heavy alcohol consumption. When comparing the off-label group to individuals with psychosis or bipolar disorder who used APs, there were less differences, though individuals with psychosis or bipolar disorder had more markers of morbidity and a lower level of education.
Conclusions: Individuals who had been prescribed APs off label had a higher level of mental and somatic morbidity and poorer socioeconomic status than individuals with non-psychotic mental disorders who did not use APs.
Acta psychiatrica Scandinavica
|Pages:||227 - 239|
|Type of Publication:||
A1 Journal article – refereed
|Field of Science:||
3124 Neurology and psychiatry
This work was supported by grants from the Academy of Finland (grant number 316563), and Oulu University Hospital funding (basic government funding for hospitals).
|Academy of Finland Grant Number:||
316563 (Academy of Finland Funding decision)
© 2022 The Authors. Acta Psychiatrica Scandinavica published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.