University of Oulu

Rydström, A, Darin-Mattsson, A, Kåreholt, I, et al. Occupational complexity and cognition in the FINGER multidomain intervention trial. Alzheimer's Dement. 2022; 18: 2438– 2447.

Occupational complexity and cognition in the FINGER multidomain intervention trial

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Author: Rydström, Anders1,2; Darin-Mattsson, Alexander2; Kåreholt, Ingemar1,2,3;
Organizations: 1Division of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden
2Aging Research Center, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden
3Institute of Gerontology, School of Health and Welfare, Aging Research Network – Jönköping (ARN-J), Jönköping University, Jönköping, Sweden
4Department of Public Health Solutions, Public Health Promotion Unit, Finnish Institute for Health and Welfare, Helsinki, Finland
5Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland
6The Ageing Epidemiology Research Unit, School of Public Health, Imperial College London, London, UK
7Center for Life Course Health Research/Geriatrics, University of Oulu, Oulu, Finland
8Medical Research Center Oulu, Oulu University Hospital and Oulu City Hospital, Oulu, Finland
9Neurocenter/Neurology, Kuopio University Hospital, Kuopio, Finland
10Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland
11Hospital District of North Karelia, Joensuu, Finland
12Work Ability and Working Careers, Finnish Institute of Occupational Health, Helsinki, Finland
13Department of Welfare; Ageing, Disability and Functioning Unit, Finnish Institute for Health and Welfare, Helsinki, Finland
14Department of Social and, Psychological Sciences, Karlstad University, Karlstad, Sweden
15University of Helsinki, Clinicum, and Helsinki University Hospital, Helsinki, Finland
16South Ostrobothnia Central Hospital, Seinäjoki, Finland
17Department of Public Health, University of Helsinki, Helsinki, Finland
18Diabetes Research Group, King Abdulaziz University, Jeddah, Saudi Arabia
19Theme Aging, Karolinska University Hospital, Stockholm, Sweden
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 0.3 MB)
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Language: English
Published: Elsevier, 2022
Publish Date: 2023-06-08


Introduction: Lifetime exposure to occupational complexity is linked to late-life cognition, and may affect benefits of preventive interventions.

Methods: In the 2-year multidomain Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER), we investigated, through post hoc analyses (N = 1026), the association of occupational complexity with cognition. Occupational complexity with data, people, and substantive complexity were classified through the Dictionary of Occupational Titles.

Results: Higher levels of occupational complexity were associated with better baseline cognition. Measures of occupational complexity had no association with intervention effects on cognition, except for occupational complexity with data, which was associated with the degree of intervention-related gains for executive function.

Discussion: In older adults at increased risk for dementia, higher occupational complexity is associated with better cognition. The cognitive benefit of the FINGER intervention did not vary significantly among participants with different levels of occupational complexity. These exploratory findings require further testing in larger studies.

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Series: Alzheimer's & dementia. The journal of the Alzheimer's Association
ISSN: 1552-5260
ISSN-E: 1552-5279
ISSN-L: 1552-5260
Volume: 18
Issue: 12
Pages: 2438 - 2447
DOI: 10.1002/alz.12561
Type of Publication: A1 Journal article – refereed
Field of Science: 3142 Public health care science, environmental and occupational health
3124 Neurology and psychiatry
Funding: This research was supported by the Karolinska Institute funding for doctoral education at KI (KID grant), Alzheimerfonden Sweden, EURO-FINGERS, an EU Joint Programme - Neurodegenerative Disease Research (JPND) project (supported through the following funding organizations under the aegis of JPND - Finland: Academy of Finland grant number 334804; Sweden: Swedish Research Council grant number 2019-02226); Swedish Research Council, Center for Innovative Medicine (CIMED) at Karolinska Institutet, Region Stockholm (ALF, NSV) grants, Knut and Alice Wallenberg Foundation, Stiftelsen Stockholms sjukhem, Konung Gustaf V:s och Drottning Victorias Frimurarstiftelse, Gun och Bertil Stohnes Stiftelse, the Karolinska Institutet fund for geriatric research, Stiftelsen Gamla Tjänarinnor, Academy of Finland, Finnish Social Insurance Institution, Finnish Ministry of Education and Culture, Alzheimer's Research & Prevention Foundation, Juho Vainio Foundation (Finland), European Research Council grant 804371, Yrjö Jahnsson Foundation (Finland), Finnish Cultural Foundation, Jalmari and Rauha Ahokas Foundation. S.S. is supported by the Swedish Research Council, Alzheimerfonden, Demensförbundet, Karolinska Institute Foundation and Funds (KI Stiftelser och Fonder), and Loo and Hans Osterman Foundation for Medical Research. The funding sources had no involvement in study design, collection, analysis or interpretation of data, writing the report, or in the decision to submit the manuscript for publication.
Copyright information: © 2021 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.