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Kuula, J., Lundbom, J., Hakkarainen, A. et al. Abdominal adipose tissue and liver fat imaging in very low birth weight adults born preterm: birth cohort with sibling-controls. Sci Rep 12, 9905 (2022). https://doi.org/10.1038/s41598-022-13936-1

Abdominal adipose tissue and liver fat imaging in very low birth weight adults born preterm : birth cohort with sibling-controls

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Author: Kuula, Juho1,2; Lundbom, Jesper1; Hakkarainen, Antti1;
Organizations: 1Department of Radiology, HUS Medical Imaging Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
2Population Health Unit, Finnish Institute for Health and Welfare, Helsinki and Oulu, Finland
3Children’s Hospital, Pediatric Research Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
4Research Program for Clinical and Molecular Metabolism (CAMM), Faculty of Medicine, University of Helsinki, Helsinki, Finland
5PEDEGO Research Unit, MRC Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland
6Psychology/Welfare Sciences, Faculty of Social Sciences, University of Tampere, Tampere, Finland
7Department of General Practice and Primary Health Care, University of Helsinki, Helsinki, Finland
8Folkhälsan Research Center, Helsinki, Finland
9Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore
10Human Potential Translational Research Programme and Department of Obstetrics and Gynecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
11Obesity Research Unit, Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland
12Obesity Center, Endocrinology, Abdominal Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland
13Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway
14Children’s Hospital, Helsinki University Hospital and University of Helsinki, Helsinki, Finland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 1.2 MB)
Persistent link: http://urn.fi/urn:nbn:fi-fe2023061655985
Language: English
Published: Springer Nature, 2022
Publish Date: 2023-06-16
Description:

Abstract

Preterm birth at very low birth weight (VLBW,  < 1500 g) is associated with an accumulation of cardiovascular and metabolic risk factors from childhood at least to middle age. Small-scale studies suggest that this could partly be explained by increased visceral or ectopic fat. We performed magnetic resonance imaging on 78 adults born preterm at VLBW in Finland between 1978 and 1990 and 72 term same-sex siblings as controls, with a mean age of 29 years. We collected T1-weighted images from the abdomen, and magnetic resonance spectra from the liver, subcutaneous abdominal adipose tissue, and tibia. The adipose tissue volumes of VLBW adults did not differ from their term siblings when adjusting for age, sex, and maternal and perinatal factors. The mean differences were as follows: subcutaneous − 0.48% (95% CI − 14.8%, 16.3%), visceral 7.96% (95% CI − 10.4%, 30.1%), and total abdominal fat quantity 1.05% (95% CI − 13.7%, 18.4%). Hepatic triglyceride content was also similar. VLBW individuals displayed less unsaturation in subcutaneous adipose tissue (− 4.74%, 95% CI − 9.2%, − 0.1%) but not in tibial bone marrow (1.68%, 95% CI − 1.86%, 5.35%). VLBW adults displayed similar adipose tissue volumes and hepatic triglyceride content as their term siblings. Previously reported differences could thus partly be due to genetic or environmental characteristics shared between siblings. The VLBW group displayed less unsaturation in subcutaneous abdominal adipose tissue, suggesting differences in its metabolic activity and energy storage.

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Series: Scientific reports
ISSN: 2045-2322
ISSN-E: 2045-2322
ISSN-L: 2045-2322
Volume: 12
Article number: 9905
DOI: 10.1038/s41598-022-13936-1
OADOI: https://oadoi.org/10.1038/s41598-022-13936-1
Type of Publication: A1 Journal article – refereed
Field of Science: 3142 Public health care science, environmental and occupational health
3123 Gynaecology and paediatrics
Subjects:
Article
Funding: This research is supported by Government Research Funds, Finnish Medical Foundation, Finnish Diabetes Research Foundation, Doctoral Programme in Clinical Research, University of Helsinki; Academy of Finland (Grants 274794 and 315680 to Eero Kajantie); the European Commission (Horizon2020 award 733280 RECAP Research on Children and Adults Born Preterm); the Finnish Foundation for Pediatric Research; Finska Läkaresällskapet; the Juho Vainio Foundation; the Paulo Foundation; the Päivikki and Sakari Sohlberg Foundation; the Jalmari and Rauha Ahokas Foundation; the Novo Nordisk Foundation; the Signe and Ane Gyllenberg Foundation; the Sigrid Jusélius Foundation; and the Yrjö Jahnsson Foundation. KHP was funded by the Academy of Finland (Grant Numbers 335443, 314383, 272376, 266286) and Novo Nordisk Foundation (NNF20OC0060547, NNF17OC0027232, NNF10OC1013354), as well as Government Research Funds, Finnish Medical Foundation, the Signe and Ane Gyllenberg Foundation, Finnish Diabetes Research Foundation, Sigrid Juselius Foundation, and University of Helsinki during the conduct of the study.
Dataset Reference: The datasets generated during and/or analysed during the current study are not publicly available due to them containing individual level data, even though the data are anonymized. The datasets are available from the corresponding author on reasonable request.
Copyright information: © The Author(s) 2022. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http:// creativecommons. org/ licenses/ by/4. 0/.
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