Korkalainen, N., Ilvesmäki, T., Parkkola, R. et al. Brain volumes and white matter microstructure in 8- to 10-year-old children born with fetal growth restriction. Pediatr Radiol 52, 2388–2400 (2022). https://doi.org/10.1007/s00247-022-05372-0
Brain volumes and white matter microstructure in 8- to 10-year-old children born with fetal growth restriction
|Author:||Korkalainen, Noora1,2; Ilvesmäki, Tero3,4; Parkkola, Riitta3,4;|
1Department of Obstetrics and Gynecology, PEDEGO Research Unit, Oulu University Hospital, Aapistie 5 A, 5000, FI-90014, Oulu, PL, Finland
2University of Oulu, Oulu, Finland
3Department of Radiology, Turku University Hospital, Turku, Finland
4Department of Radiology, University of Turku, Turku, Finland
5Department of Radiology, Oulu University Hospital, Oulu, Finland
6Department of Obstetrics and Gynecology, Turku University Hospital, Turku, Finland
|Online Access:||PDF Full Text (PDF, 1 MB)|
|Persistent link:|| http://urn.fi/urn:nbn:fi-fe2023062759994
|Publish Date:|| 2023-06-27
Background: Fetal growth restriction caused by placental insufficiency is associated with increased risk of poor neurodevelopment, even in the absence of specific perinatal brain injury. Placental insufficiency leads to chronic hypoxaemia that may alter cerebral tissue organisation and maturation.
Objective: The aim of this study was to assess the effects fetal growth restriction and fetal haemodynamic abnormalities have on brain volumes and white matter microstructure at early school age.
Materials and methods: This study examined 32 children born with fetal growth restriction at 24 to 40 gestational weeks, and 27 gestational age-matched children, who were appropriate for gestational age. All children underwent magnetic resonance imaging (MRI) at the age of 8–10 years. Cerebral volumes were analysed, and tract-based spatial statistics and atlas-based analysis of white matter were performed on 17 children born with fetal growth restriction and 14 children with birth weight appropriate for gestational age.
Results: Children born with fetal growth restriction demonstrated smaller total intracranial volumes compared to children with normal fetal growth, whereas no significant differences in grey or white matter volumes were detected. On atlas-based analysis of white matter, children born with fetal growth restriction demonstrated higher mean and radial diffusivity values in large white matter tracts when compared to children with normal fetal growth.
Conclusion: Children ages 8–10 years old born with fetal growth restriction demonstrated significant changes in white matter microstructure compared to children who were appropriate for gestational age, even though no differences in grey and white matter volumes were detected. Poor fetal growth may impact white matter maturation and lead to neurodevelopmental impairment later in life.
|Pages:||2388 - 2400|
|Type of Publication:||
A1 Journal article – refereed
|Field of Science:||
3123 Gynaecology and paediatrics
Open Access funding provided by University of Oulu including Oulu University Hospital. Oulu University Health and Biosciences Doctoral Programme (NK), The Instrumentarium Science Foundation (NK), The Finnish Cultural Foundation (NK) and The Finnish Medical Foundation (KM).
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