Rayan Mroueh, Timo Carpén, Antti Mäkitie, Johnni Hansen, Sanna Heikkinen, Elsebeth Lynge, Jan Ivar Martinsen, Jenny Selander, Ingrid Sivesind Mehlum, Jóhanna Eyrún Torfadottir, Tuula Salo & Eero Pukkala (2023) Occupational variation in the incidence of lip cancer in the Nordic countries, Acta Oncologica, 62:6, 541-549, DOI: 10.1080/0284186X.2023.2224053
Occupational variation in the incidence of lip cancer in the Nordic countries
|Author:||Mroueh, Rayan1,2,3; Carpén, Timo1,3,4; Mäkitie, Antti1,3,5;|
1Department of Otorhinolaryngology – Head and Neck Surgery, HUS Helsinki University Hospital, University of Helsinki, Helsinki, Finland
2Finnish Cancer Registry, Institute for Statistical and Epidemiological Cancer and Research, Helsinki, Finland
3Research Program in Systems Oncology, Faculty of Medicine, University of Helsinki, Helsinki, Finland
4Department of Pathology, HUS Helsinki University Hospital, University of Helsinki, Helsinki, Finland
5Division of Ear, Nose and Throat Diseases, Department of Clinical Sciences, Intervention and Technology, Karolinska Institutet and Karolinska Hospital, Stockholm, Sweden
6Danish Cancer Society Research Center, Copenhagen, Denmark
7Nykøbing Falster Hospital, University of Copenhagen, Nykøbing Falster, Denmark
8Department of Research, Cancer Registry of Norway, Oslo, Norway
9Institute of Environmental Medicine, IMM Karolinska Institutet, Stockholm, Sweden
10National Institute of Occupational Health (STAMI), Oslo, Norway
11Institute of Health and Society, University of Oslo, Oslo, Norway
12Icelandic Cancer Registry, Reykjavik, Iceland
13Centre of Public Health Sciences, Faculty of Medicine, University of Iceland, Reykjavik, Iceland
14Cancer and Translational Medicine Unit, University of Oulu, Medical Research Unit, Oulu University Hospital, Oulu, Finland
15Oral and Maxillofacial Diseases, University of Helsinki, and Haartman Institute, Helsinki, Finland
16Health Sciences Unit, Faculty of Social Sciences, Tampere University, Tampere, Finland
|Persistent link:|| http://urn.fi/urn:nbn:fi-fe2023070583082
|Publish Date:|| 2024-06-19
Introduction: While certain occupations, such as agriculture and fishery, have been associated with an increased risk of lip cancer, the occupational risk profile of lip cancer and its change over time remain poorly known. This study aims to evaluate the incidence of lip cancer across different occupations in the Nordic countries.
Methods: The Nordic Occupational Cancer Study (NOCCA) covers 14.9 million people and includes 45 years of cancer incidence data, from 1961 to 2005, linked to occupational categories for all the five Nordic populations. Standardized incidence ratios (SIRs) with 95% confidence intervals (CIs) were used to quantify the risk of lip cancer across occupational categories relative to the entire national populations.
Results: There were a total of 14,477 male and 3008 female lip cancer patients identified during follow up. The highest SIRs were observed among male fishermen (SIR 2.26, 95% CI: 2.04–2.50), gardeners (SIR 1.60, 95% CI: 1.48–1.72), and farmers (SIR 1.60, 95% CI: 1.55–1.66). A significantly reduced risk of lip cancer (SIR < 0.50) was observed among male physicians, teachers, religious workers, artistic workers, journalists, administrators, printers, waiters, and hairdressers. Among women, no occupations were associated with an increased risk of lip cancer.
Conclusions: The incidence of lip cancer varies widely between outdoor and indoor occupations. Occupations involving outdoor activity and exposure to sunlight show the most elevated SIRs.
|Pages:||541 - 549|
|Type of Publication:||
A1 Journal article – refereed
|Field of Science:||
This work was supported by Finska Läkaresällskapet, the Helsinki University Hospital Research Funding, and Nordic Cancer Union (NCU).
This is an Accepted Manuscript version of the following article, accepted for publication in Acta Oncologica. Rayan Mroueh, Timo Carpén, Antti Mäkitie, Johnni Hansen, Sanna Heikkinen, Elsebeth Lynge, Jan Ivar Martinsen, Jenny Selander, Ingrid Sivesind Mehlum, Jóhanna Eyrún Torfadottir, Tuula Salo & Eero Pukkala (2023) Occupational variation in the incidence of lip cancer in the Nordic countries, Acta Oncologica, DOI: 10.1080/0284186X.2023.2224053. It is deposited under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.