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Tertiary lymphoid structures associate with improved survival in early oral tongue cancer |
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| Author: | Almangush, Alhadi1,2,3,4; Bello, Ibrahim O.1,5; Elseragy, Amr6,7; |
| Organizations: |
1Department of Pathology, University of Helsinki, Haartmaninkatu 3, P.O. Box 21, Helsinki, N00014, Finland 2Faculty of Medicine, Research Program in Systems Oncology, University of Helsinki, Helsinki, Finland 3Institute of Biomedicine, Pathology, University of Turku, Turku, Finland
4Faculty of Dentistry, Misurata University, Misurata, Libya
5Department of Oral Medicine and Diagnostic Sciences, King Saud University College of Dentistry, Riyadh, Saudi Arabia 6Cancer and Translational Medicine Research Unit, University of Oulu, 90014, Oulu, Finland 7Department of Oral and Maxillofacial Diseases, University of Helsinki, Helsinki, Finland 8Research Programs Unit, Translational Cancer Medicine, University of Helsinki, Helsinki, Finland 9Department of Oral Pathology and Radiology, University of Turku, Turku, Finland 10Research Programs Unit, Translational Cancer Medicine, University of Helsinki, P.O. Box 63, 00014, Helsinki, Finland 11Department of Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland 12Department of Head and Neck Surgery and Otorhinolaryngology, A.C. Camargo Cancer Center, and University of Sao Paulo Medical School, Department of Head and Neck Surgery, São Paulo, SP, 05402-000, Brazil 13Medical Informatics and Data Analysis Research Group, University of Oulu, Oulu, Finland 14Department of Oral Diagnosis and Graduate Program in Oral Biology, School of Dentistry, University of Campinas, Piracicaba, São Paulo, 13414-018, Brazil 15Department of Otorhinolaryngology – Head and Neck Surgery, University of Helsinki and Helsinki University Hospital, P.O. Box 263, 00029, Helsinki, Finland 16Department of Clinical Sciences, Intervention and Technology, Division of Ear, Nose and Throat Diseases, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden 17Institute of Biomedicine, Pathology, University of Turku, 20520, Turku, Finland 18Turku University Central Hospital, Turku, Finland |
| Format: | article |
| Version: | published version |
| Access: | open |
| Online Access: | PDF Full Text (PDF, 1.3 MB) |
| Persistent link: | http://urn.fi/urn:nbn:fi-fe2023070586499 |
| Language: | English |
| Published: |
Springer Nature,
2022
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| Publish Date: | 2023-07-05 |
| Description: |
AbstractBackground: The clinical significance of tertiary lymphoid structures (TLSs) is not well-documented in early oral tongue squamous cell carcinoma (OTSCC). Methods: A total of 310 cases of early (cT1-2N0) OTSCC were included in this multicenter study. Assessment of TLSs was conducted on hematoxylin and eosin-stained sections. TLSs were assessed both in the central part of the tumor and at the invasive front area. Results: The presence of TLSs associated with improved survival of early OTSCC as presented by Kaplan–Meier survival analyses for disease-specific survival (P = 0.01) and overall survival (P = 0.006). In multivariable analyses, which included conventional prognostic factors, the absence of TLSs associated with worse disease-specific survival with a hazard ratio (HR) of 1.96 (95% CI 1.09–3.54; P = 0.025) and poor overall survival (HR 1.66, 95% CI 1.11–2.48; P = 0.014). Conclusion: Histological evaluation of TLSs predicts survival in early OTSCC. TLSs showed superior prognostic power independent of routine WHO grading and TNM staging system. see all
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| Series: |
BMC cancer |
| ISSN: | 1471-2407 |
| ISSN-E: | 1471-2407 |
| ISSN-L: | 1471-2407 |
| Volume: | 22 |
| Issue: | 1 |
| Article number: | 1108 |
| DOI: | 10.1186/s12885-022-10208-z |
| OADOI: | https://oadoi.org/10.1186/s12885-022-10208-z |
| Type of Publication: |
A1 Journal article – refereed |
| Field of Science: |
3122 Cancers |
| Subjects: | |
| Funding: |
This study was funded by Turku University Hospital Fund, Helsinki University Hospital Research Fund, the Finnish Dental Society (Apollonia), the Finnish Cancer Society, Finska Läkaresällskapet, K. Albin Johanssons Stiftelse, and the Maritza and Reino Salonen Foundation. The funders took no part in the design or performance of the study. Funding consists of academic grants without any engagements considering the research project. Open access funded by Helsinki University Library. |
| Copyright information: |
© The Author(s) 2022, corrected publication 2022. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
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https://creativecommons.org/licenses/by/4.0/ |