University of Oulu

Sara Simorgh, Neda Alasvand, Mahboobe Khodadadi, Faezeh Ghobadi, Maziar Malekzadeh Kebria, Peiman Brouki Milan, Saeid Kargozar, Francesco Baino, Ali Mobasheri, Masoud Mozafari, Additive manufacturing of bioactive glass biomaterials, Methods, Volume 208, 2022, Pages 75-91, ISSN 1046-2023,

Additive manufacturing of bioactive glass biomaterials

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Author: Simorgh, Sara1,2; Alasvand, Neda2,3; Khodadadi, Mahboobe3;
Organizations: 1Cellular and Molecular Research Centre, Iran University of Medical Sciences, Tehran, Iran
2Department of Tissue Engineering and Regenerative Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran
3Department of Nanotechnology and Advanced Materials, Materials and Energy Research Center (MERC), Tehran, Iran
4Department of Chemical and Petroleum Engineering, Sharif University of Technology, Tehran, Iran
5Tissue Engineering Research Group (TERG), Department of Anatomy and Cell Biology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
6Institute of Materials Physics and Engineering, Department of Applied Science and Technology (DISAT), Politecnico di Torino, Corso Duca degli Abruzzi 24, 10129 Torino, Italy
7Research Unit of Health Sciences and Technology, Faculty of Medicine, University of Oulu, Oulu, Finland
8Department of Regenerative Medicine, State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania
9Department of Joint Surgery, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
10World Health Organization Collaborating Centre for Public Health Aspects of Musculoskeletal Health and Aging, Liege, Belgium
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 15.2 MB)
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Language: English
Published: Elsevier, 2022
Publish Date: 2023-07-05


Tissue engineering (TE) and regenerative medicine have held great promises for the repair and regeneration of damaged tissues and organs. Additive manufacturing has recently appeared as a versatile technology in TE strategies that enables the production of objects through layered printing. By applying 3D printing and bioprinting, it is now possible to make tissue-engineered constructs according to desired thickness, shape, and size that resemble the native structure of lost tissues. Up to now, several organic and inorganic materials were used as raw materials for 3D printing; bioactive glasses (BGs) are among the most hopeful substances regarding their excellent properties (e.g., bioactivity and biocompatibility). In addition, the reported studies have confirmed that BG-reinforced constructs can improve osteogenic, angiogenic, and antibacterial activities. This review aims to provide an up-to-date report on the development of BG-containing raw biomaterials that are currently being employed for the fabrication of 3D printed scaffolds used in tissue regeneration applications with a focus on their advantages and remaining challenges.

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Series: Methods
ISSN: 1046-2023
ISSN-E: 1095-9130
ISSN-L: 1046-2023
Volume: 208
Pages: 75 - 91
DOI: 10.1016/j.ymeth.2022.10.010
Type of Publication: A2 Review article in a scientific journal
Field of Science: 217 Medical engineering
Copyright information: © 2022 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (