University of Oulu

Gudauskaitė, G., Kairienė, I., Ivaškienė, T., Rascon, J., Mobasheri, A. (2022). Therapeutic Perspectives for the Clinical Application of Umbilical Cord Hematopoietic and Mesenchymal Stem Cells: Overcoming Complications Arising After Allogeneic Hematopoietic Stem Cell Transplantation. In: Turksen, K. (eds) Cell Biology and Translational Medicine, Volume 18. Advances in Experimental Medicine and Biology(), vol 1409. Springer, Cham.

Therapeutic perspectives for the clinical application of umbilical cord hematopoietic and mesenchymal stem cells : overcoming complications arising after allogeneic hematopoietic stem cell transplantation

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Author: Gudauskaitė, Greta1; Kairienė, Ignė2; Ivaškienė, Tatjana1;
Organizations: 1State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania
2Faculty of Medicine, Vilnius University, Vilnius, Lithuania
3Research Unit of Medical Imaging, Physics and Technology, Faculty of Medicine, University of Oulu, Oulu, Finland
4Department of Joint Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
5World Health Organization Collaborating Centre for Public Health Aspects of Musculoskeletal Health and Aging, Université de Liège, Liège, Belgium
Format: article
Version: accepted version
Access: embargoed
Persistent link:
Language: English
Published: Springer Nature, 2023
Publish Date: 2024-08-23


This review focuses on the therapeutic features of umbilical cord blood (UCB) cells as a source for allogeneic hematopoietic stem cell transplantation (aHSCT) in adult and child populations to treat malignant and nonmalignant hematologic diseases, genetic disorders, or pathologies of the immune system, when standard treatment (e.g., chemotherapy) is not effective or clinically contraindicated. In this article, we summarize the immunological properties and the advantages and disadvantages of using UCB stem cells and discuss a variety of treatment outcomes using different sources of stem cells from different donors both in adults and pediatric population. We also highlight the critical properties (total nucleated cell dose depending on HLA compatibility) of UCB cells that reach better survival rates, reveal the advantages of double versus single cord blood unit transplantation, and present recommendations from the most recent studies. Moreover, we summarize the mechanism of action and potential benefit of mesenchymal umbilical cord cells and indicate the most common posttransplantation complications.

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Series: Advances in experimental medicine and biology
ISSN: 0065-2598
ISSN-E: 2214-8019
ISSN-L: 0065-2598
ISBN: 978-3-031-28424-3
ISBN Print: 978-3-031-28423-6
Issue: 1409
Pages: 111 - 126
DOI: 10.1007/5584_2022_726
Host publication: Cell Biology and Translational Medicine, Volume 18
Host publication editor: Turksen, Kursad
Type of Publication: A3 Book chapter
Field of Science: 3121 General medicine, internal medicine and other clinical medicine
318 Medical biotechnology
Copyright information: © 2022 Springer Nature Switzerland AG. This version of the article has been accepted for publication, after peer review (when applicable) but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: Use of this Accepted Version is subject to the publisher’s Accepted Manuscript terms of use