University of Oulu

Oleksii Sieryi, Yuriy Ushenko, Volodimir Ushenko, Olexander Dubolazov, Anastasia V. Syvokorovskaya, Oleh Vanchulyak, Alexander G. Ushenko, Mykhailo Gorsky, Yuriy Tomka, Alexander Bykov, Wenjun Yan, and Igor Meglinski, "Optical anisotropy composition of benign and malignant prostate tissues revealed by Mueller-matrix imaging," Biomed. Opt. Express 13, 6019-6034 (2022),

Optical anisotropy composition of benign and malignant prostate tissues revealed by Mueller-matrix imaging

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Author: Sieryi, Oleksii1; Ushenko, Yuriy2; Ushenko, Volodimir2;
Organizations: 1Optoelectronics and Measurement Techniques, University of Oulu, Oulu, Finland
2Optics and Publishing Department, Chernivtsi National University, Chernivtsi, Ukraiine
3Department of Forensic Medicine and Medical Law, Bukovinian State Medical University, Chernivtsi, Ukraine
4College of Electrical Engineering, Taizhou Research Institute, Zhejiang University, Taizhou, China
5College of Engineering and Physical Sciences, Aston University, Birmingham, UK
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 4.9 MB)
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Language: English
Published: Optical Society of America, 2022
Publish Date: 2023-07-07


A Mueller matrix imaging approach is employed to disclose the three-dimensional composition framework of optical anisotropy within cancerous biotissues. Visualized by the Mueller matrix technique spatial architecture of optical anisotropy of tissues is characterised by high-order statistical moments. Thus, quantitative analysis of the spatial distribution of optical anisotropy, such as linear and circular birefringence and dichroism, is revealed by using high-order statistical moments, enabling definitively discriminate prostate adenoma and carcinoma. The developed approach provides greater (>90%) accuracy of diagnostic achieved by using either the 3-rd or 4-th order statistical moments of the linear anisotropy parameters. Noticeable difference is observed between prostate adenoma and carcinoma tissue samples in terms of the extinction coefficient and the degree of depolarisation. Juxtaposition to other optical diagnostic modalities demonstrates the greater accuracy of the approach described herein, paving the way for its wider application in cancer diagnosis and tissue characterization.

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Series: Biomedical optics express
ISSN: 2156-7085
ISSN-E: 2156-7085
ISSN-L: 2156-7085
Volume: 13
Issue: 11
Article number: 6019
DOI: 10.1364/boe.464420
Type of Publication: A1 Journal article – refereed
Field of Science: 114 Physical sciences
Funding: Royal Society (APX111232); National Research Foundation of Ukraine (2020.02/0061); ATTRACT Horizon 2020 Framework Programme for Research and Innovation (1010004462); Academy of Finland (314639, 325097, 351068).
Academy of Finland Grant Number: 325097
Detailed Information: 325097 (Academy of Finland Funding decision)
351068 (Academy of Finland Funding decision)
Copyright information: Journal © 2022. Published by Optica Publishing Group under the terms of the Creative Commons Attribution 4.0 License. Further distribution of this work must maintain attribution to the author(s) and the published article's title, journal citation, and DOI.