Tatiana Boronikhina, Gennadii Piavchenko, Artem Venediktov, Ekaterina Kustavinova, Svetlana Mukhamedova, Natalia Kartashkina, Sergey Kuznetsov, Igor Meglinski, Alexander Yatskovskiy, The number of the intraepithelial T cells correlate with the proliferation index in human bulbourethral gland epithelium, Heliyon, Volume 8, Issue 11, 2022, e11658, ISSN 2405-8440, https://doi.org/10.1016/j.heliyon.2022.e11658
The number of the intraepithelial T cells correlate with the proliferation index in human bulbourethral gland epithelium
|Author:||Boronikhina, Tatiana1; Piavchenko, Gennadii1; Venediktov, Artem1;|
1Department of Histology, Cytology, and Embryology, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia
2Opto-Electronics and Measurement Techniques, Faculty of Information and Electrical Engineering, University of Oulu, Oulu, Finland
3College of Engineering and Physical Sciences, Aston University, Birmingham, UK
|Online Access:||PDF Full Text (PDF, 1.9 MB)|
|Persistent link:|| http://urn.fi/urn:nbn:fi-fe2023070790387
|Publish Date:|| 2023-07-07
Background: Our study has immunohistochemically examined T cells localization and number as well as proliferative activity level for the bulbourethral gland epithelium in men of different ages, using monoclonal antibodies against CD45RO and proliferating cell nuclear antigen (PCNA).
Results: We have found that the T cells have been localized mainly in excretory ducts epithelium of the glands in any age group, meanwhile their relative number varies with age. The excretory ducts epithelium has shown a high proliferative activity when in acini the PCNA index has been low. Postnatal dynamics of the epithelium proliferative activity positively correlates with age-related density fluctuations in lymphocytic infiltration of the glands.
Conclusions: We consider that intraepithelial T cells may contribute to the regulation of epithelial cells proliferation in the bulbourethral glands.
|Type of Publication:||
A1 Journal article – refereed
|Field of Science:||
213 Electronic, automation and communications engineering, electronics
Dr. Gennadii Piavchenko acknowledges the support of Ministry of Science and Higher Education of the Russian Federation [075-15-2020-926]. Prof. Igor Meglinski acknowledges the partial support of innovative programme  and the Leverhulme Trust and The Royal Society [APX111232 APEX Awards 2021] and the Academy of Finland . Dr. Gennadii Piavchenko and Prof. Igor Meglinski also acknowledge the support from the Academy of Finland .
|Academy of Finland Grant Number:||
351068 (Academy of Finland Funding decision)
325097 (Academy of Finland Funding decision)
© 2022 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).