University of Oulu

Matta, C., Takács, R., Ducza, L., Ebeid, R. A., Choi, H., & Mobasheri, A. (2023). Ion channels involved in inflammation and pain in osteoarthritis and related musculoskeletal disorders. American Journal of Physiology-Cell Physiology, 325(1), C257–C271.

Ion channels involved in inflammation and pain in osteoarthritis and related musculoskeletal disorders

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Author: Matta, Csaba1; Takács, Roland1; Ducza, László1;
Organizations: 1Department of Anatomy, Histology and Embryology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary
2Healthcare Research Institute, Kolon Advanced Research Center, Kolon Industries, Inc., Seoul, South Korea
3Research Unit of Medical Imaging, Physics and Technology, Faculty of Medicine, University of Oulu, Oulu, Finland
4Department of Regenerative Medicine, State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania
5Department of Orthopedics, University Medical Center Utrecht, Utrecht, The Netherlands
6Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
7Department of Joint Surgery, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China
8World Health Organization Collaborating Center for Public Health Aspects of Musculoskeletal Health and Aging, Université de Liège, Liège, Belgium
Format: article
Version: accepted version
Access: embargoed
Persistent link:
Language: English
Published: American Physiological Society, 2023
Publish Date: 2024-06-28


Osteoarthritis (OA) is a currently incurable, chronic, progressive, and debilitating musculoskeletal (MSK) condition. One of its hallmark symptoms is chronic nociceptive and neuropathic pain, which significantly reduces the quality of life of patients with OA. Although research into the pathomechanisms of OA pain is ongoing and several pain pathways are well understood, the true source of OA pain remains unclear. Ion channels and transporters are key mediators of nociceptive pain. In this narrative review article, we summarize the state-of-the-art in relation to the distribution and function of ion channels in all major synovial joint tissues in the context of pain generation. We provide an update on the ion channels likely involved in mediating peripheral and central nociceptive pathways in the nervous system in OA pain, including voltage-gated sodium and potassium channels, members of the transient receptor potential (TRP) channel family, and purinergic receptor complexes. We focus on ion channels and transporters that have the potential to be candidate drug targets for pain management in patients with OA. We propose that ion channels expressed by the cells of constituent tissues of OA-afflicted synovial joints including cartilage, bone, synovium, ligament, and muscle, should be more thoroughly investigated and targeted in the context of OA pain. Based on key findings from recent basic research articles as well as clinical trials, we propose novel directions for the development of future analgesic therapies to improve the quality of life of patients with OA.

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Series: American journal of physiology. Cell physiology
ISSN: 0363-6143
ISSN-E: 1522-1563
ISSN-L: 0363-6143
Volume: 325
Issue: 1
Pages: C257 - C271
DOI: 10.1152/ajpcell.00040.2023
Type of Publication: A2 Review article in a scientific journal
Field of Science: 3121 General medicine, internal medicine and other clinical medicine
Funding: CM was supported by the Young Researcher Excellence Program (grant number: FK-134304) of the National Research, Development and Innovation Office, Hungary. AM acknowledges financial support from the European Structural and Social Funds through the Research Council of Lithuania (Lietuvos Mokslo Taryba), according to the Program Attracting Foreign Researchers for Research Implementation (Grant No. 01.2.2-LMT-K-718-02-0022) and the Academy of Finland through the Profi6 336449 grant awarded to the University of Oulu. CM, RT, and AM also acknowledge financial support from the European Cooperation in Science and Technology (COST) Association, Action CA21110 – Building an open European Network on OsteoArthritis research (NetwOArk; actions/CA21110/).
Academy of Finland Grant Number: 336449
Detailed Information: 336449 (Academy of Finland Funding decision)
Copyright information: © 2023 the American Physiological Society.