Haarala, AK, Sinikumpu, S-P, Jokelainen, J, Pekkanen, J, Huilaja, L. Associative factors for atopic dermatitis and other atopic diseases in middle-aged adults: a population-based birth cohort study among 5373 subjects. Health Sci Rep. 2022; 6:e1015. doi:10.1002/hsr2.1015
Associative factors for atopic dermatitis and other atopic diseases in middle-aged adults : a population-based birth cohort study among 5373 subjects
|Author:||Haarala, Anna K.1,2; Sinikumpu, Suvi-Päivikki1,2; Jokelainen, Jari3;|
1The Department of Dermatology, University Hospital of Oulu, PEDEGO Research Unit, Oulu, Finland
2Medical Research Center, PEDEGO Research Group, University of Oulu, Oulu, Finland
3Infrastructure for Population Studies, Faculty of Medicine, University of Oulu, Oulu, Finland
4Department of Public Health, University of Helsinki, Helsinki, Finland
5Finnish Institute for Health and Welfare, Helsinki, Finland
6Department of Health Security, Environmental Health, Finnish Institute for Health and Welfare, Kuopio, Finland
|Online Access:||PDF Full Text (PDF, 1.3 MB)|
|Persistent link:|| http://urn.fi/urn:nbn:fi-fe2023071390592
John Wiley & Sons,
|Publish Date:|| 2023-07-13
Background and aims: The study aimed to examine parental, longitudinal and current associative factors for atopic dermatitis (AD) and to compare those to other atopic diseases in 46-year-old adults.
Methods: Questionnaire data from the Northern Finland Birth Cohort 1966 study were used. To analyze allergic sensitization, skin prick tests (n = 5373) were performed for birch, timothy, cat, and house dust mite at age 46.
Results: Maternal (odds ratio [OR] 1.81; 95% confidence interval [CI] 1.25–2.59) and paternal allergy (OR 2.54; CI 1.76–3.64), sensitization to any of the four tested aeroallergens (OR 1.56; CI 1.04–2.30) as well as polysensitization (OR 3.04; CI 2.10–4.37) were associated with current AD. Living on a farm in infancy was negatively associated with allergic rhinitis, allergic conjunctivitis, and atopic multimorbidity. Current AD (OR 2.65; CI 1.44–4.60) and all atopic diseases associated with indoor air related symptoms. Current AD associated with other atopic diseases, most strongly with allergic rhinitis (OR 4.92; CI 3.92–6.22).
Conclusion: Current AD in a 46-year-old general population occurred frequently with allergic rhinitis, allergic conjunctivitis, and asthma in the Northern Finland Birth Cohort study 1966. Parental allergy and sensitization to common aeroallergens were found as shared associative factors for AD, allergic rhinitis, allergic conjunctivitis, and asthma. AD and other atopic diseases associated with symptoms related to poor indoor air quality. In daily practice, it is important to take these comorbidities into consideration when treating patients with AD.
Health science reports
|Type of Publication:||
A1 Journal article – refereed
|Field of Science:||
3121 General medicine, internal medicine and other clinical medicine
© 2022 The Authors. Health Science Reports published by Wiley Periodicals LLC. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.