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A prognostic score based on B cell and plasma cell densities compared to T cell densities in colorectal cancer |
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| Author: | Karjalainen, Henna1; Sirniö, Päivi1,2; Tuomisto, Anne1; |
| Organizations: |
1Cancer and Translational Medicine Research Unit, University of Oulu, POB 5000, 90014, Oulu, Finland 2Department of Pathology, Medical Research Center Oulu, Oulu University Hospital, Oulu, Finland |
| Format: | article |
| Version: | published version |
| Access: | open |
| Online Access: | PDF Full Text (PDF, 1.6 MB) |
| Persistent link: | http://urn.fi/urn:nbn:fi-fe2023071390601 |
| Language: | English |
| Published: |
Springer Nature,
2023
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| Publish Date: | 2023-07-13 |
| Description: |
AbstractPurpose: The purpose of this study was to compare a B cell/plasma cell–based scoring system to T cell score and evaluate their prognostic value in colorectal cancer. Methods: We used immunohistochemistry to analyze the expression of CD20, CD138, CD3, and CD8 in 221 colorectal cancer patients. CD20+ B cell and CD138+ plasma cell densities in the tumor center and invasive margin were calculated and converted into a B cell/plasma cell score. T cell score was defined similarly, using CD3+ and CD8+ T cell densities. Their associations with tumor and patient characteristics and survival were analyzed. Results: Kaplan–Meier analysis showed a high B cell/plasma cell score was associated with a tendency towards longer survival (p = 0.089), but no statistically significant association was found. High T cell score associated with longer cancer-specific survival in Kaplan–Meier analysis and multivariable Cox regression analysis (p < 0.001). Additionally, high T cell score associated with lower disease stage (p < 0.001) and lesser lymphovascular invasion (p = 0.020). Conclusions: High T cell score is associated with longer survival and clinicopathological factors typical to less aggressive tumors. This study did not support the additional prognostic value of B cell/plasma cell quantification. see all
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| Series: |
International journal of colorectal disease |
| ISSN: | 0179-1958 |
| ISSN-E: | 1432-1262 |
| ISSN-L: | 0179-1958 |
| Volume: | 38 |
| Issue: | 1 |
| Article number: | 47 |
| DOI: | 10.1007/s00384-023-04322-y |
| OADOI: | https://oadoi.org/10.1007/s00384-023-04322-y |
| Type of Publication: |
A1 Journal article – refereed |
| Field of Science: |
3122 Cancers |
| Subjects: | |
| Funding: |
Open Access funding provided by University of Oulu including Oulu University Hospital. Juha P. Väyrynen was supported by grant from Cancer Foundation Finland (59–5619). |
| Copyright information: |
© The Author(s) 2023. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
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https://creativecommons.org/licenses/by/4.0/ |