Nuutinen S, Ronkainen E, Perhomaa M, Harju T, Sinikumpu J-J, Serlo W, Dunder T. Long-Term Results of Pediatric Congenital Pulmonary Malformation: A Population-Based Matched Case–Control Study with a Mean 7-Year Follow-Up. Children. 2023; 10(1):71. https://doi.org/10.3390/children10010071
Long-term results of pediatric congenital pulmonary malformation : a population-based matched case–control study with a mean 7-year follow-up
|Author:||Nuutinen, Susanna1,2; Ronkainen, Eveliina1,3; Perhomaa, Marja4,5;|
1Research Unit of Clinical Medicine, Medical Research Center (MRC) Oulu, Oulu University Hospital, University of Oulu, 90220 Oulu, Finland
2Division of Pediatric Surgery, Department of Children and Adolescents, Oulu University Hospital, University of Oulu, 90220 Oulu, Finland
3Division of Neonatal Medicine, Department of Children and Adolescents, Oulu University Hospital, University of Oulu, 90220 Oulu, Finland
4Division of Pediatric Radiology, Department of Radiology, Oulu University Hospital, University of Oulu, 90220 Oulu, Finland
5Research Unit of Medical Imaging, Physics and Technology (MIPT), Oulu University Hospital, University of Oulu, 90220 Oulu, Finland
6Research Unit of Internal Medicine, Medical Research Center (MRC) Oulu, Oulu University Hospital, University of Oulu, 90220 Oulu, Finland
7Pulmonary Unit, Department of Medicine, Oulu University Hospital, University of Oulu, 90220 Oulu, Finland
8Division of Allergology and Pulmonology, Department of Children and Adolescents, Oulu University Hospital, University of Oulu, 90220 Oulu, Finland
|Online Access:||PDF Full Text (PDF, 1.5 MB)|
|Persistent link:|| http://urn.fi/urn:nbn:fi-fe2023080994475
Multidisciplinary Digital Publishing Institute,
|Publish Date:|| 2023-08-09
Symptomatic congenital pulmonary malformations (CPMs) are a group of anomalies involving the lungs. The long-term outcomes of these patients are not well known. The present research aimed to study the pulmonary function, respiratory morbidity, and health-related quality of life (QoL) of patients treated for CPMs. All children (<16 years of age) treated for CPMs in 2002–2012 (in Oulu University Hospital) were invited to the follow-up visit. Altogether, there were 22 patients, out of which 17 (77%) participated. The mean follow-up time was 6.6 (ranged from 3 to 16) years. Pulmonary function tests, diffusing capacity, respiratory morbidity, and QoL were determined as the primary outcomes. Potential residual malformations and lung anatomy were investigated using computer tomography (CT) imaging. The outcomes were compared to the age- and sex-matched healthy controls. The forced expiratory volume at 1 s (FEV₁, Z-score) remained lower in operated patients compared to the healthy controls (−1.57 ± SD 1.35 vs. −0.39 ± SD −0.86, p-value 0.005). There were no differences in respiratory morbidity or QoL between the patients and the controls. The surgical approach (lobectomy vs. partial resection) did not affect lung function. A younger age (<1 year of age) at the time of the surgery seemed to result in a higher lung capacity, but the finding was not statistically significant. Patients with CPMs treated with surgery were satisfied with their wellbeing in the long-term. A lower lung function did not have an impact on their wellbeing. However, there was a slight decrease in lung function compared to the healthy controls, and a clinical follow-up of the patients was recommended.
|Type of Publication:||
A1 Journal article – refereed
|Field of Science:||
3123 Gynaecology and paediatrics
This research was funded by the Alma and K.A. Snellmann Foundation (0512/21), Oulu, Finland, and the Foundation for Pediatric Research, Helsinki, Finland (1001/2018).
© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).