University of Oulu

Zarrintaj, P., Seidi, F., Youssefi Azarfam, M., Khodadadi Yazdi, M., Erfani, A., Barani, M., Chauhan, N. P. S., Rabiee, N., Kuang, T., Kucinska-Lipka, J., Saeb, M. R., & Mozafari, M. (2023). Biopolymer-based composites for tissue engineering applications: A basis for future opportunities. Composites Part B: Engineering, 258, 110701.

Biopolymer-based composites for tissue engineering applications : a basis for future opportunities

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Author: Zarrintaj, Payam1,2; Seidi, Farzad1; Youssefi Azarfam, Mohamadreza3;
Organizations: 1Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources and Joint International Research Lab of Lignocellulosic Functional Materials, Nanjing Forestry University, Nanjing, 210037, China
2School of Chemical Engineering, Oklahoma State University, 420 Engineering North, Stillwater, OK, 74078, United States
3Department of Chemistry, Oklahoma State University, Stillwater, OK, 74078, United States
4Center of Excellence in Electrochemistry, Faculty of Chemistry, University of Tehran, P.O. Box 14155-6455, Tehran, Iran
5Medical Mycology and Bacteriology Research Center, Kerman University of Medical Sciences, Kerman 7616913555, Iran
6Department of Chemistry, Faculty of Science, Bhupal Nobles' University, Rajasthan, India
7Centre for Molecular Medicine and Innovative Therapeutics, Murdoch University, Perth, WA 6150, Australia
8School of Engineering, Macquarie University, Sydney, New South Wales, 2109, Australia
9College of Material Science and Engineering, Zhejiang University of Technology, Hangzhou, 310014, China
10Department of Polymer Technology, Faculty of Chemistry, Gdańsk University of Technology, G. Narutowicza 11/12, 80-233, Gdańsk, Poland
11Research Unit of Health Sciences and Technology, Faculty of Medicine, University of Oulu, Oulu, Finland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 13.2 MB)
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Language: English
Published: Elsevier, 2023
Publish Date: 2023-08-11


Biomimetic scaffolds supporting tissue regeneration are complex materials with multifunctional characteristics. The unique biocompatibility and biodegradability of biopolymers make them excellent candidates for tissue engineering and regenerative medicine. Biopolymers, which have a wide range of properties, can be obtained from different natural sources. Depending on the target tissue, biopolymers can be engineered to meet a series of specific functions. We review different types of biopolymers and their composites, besides their interactions with specific cells and tissues. Specific cellular mechanisms in tissue regeneration are also considered to elucidate the effects of biopolymers on controlling cellular mechanisms given their advantages and challenging aspects. Furthermore, the modifications required to mimic the properties of neural, cardiac, bone, and skin tissues are discussed. Utilization of biopolymer-based composites in tissue engineering requires additional improvements, where several challenges should be overcome. This work is mainly focused on biopolymers used in tissue engineering, providing support for engineering of future biocomposites for the same purpose. Some examples of biocomposites are also provided, a general guide for selection of biopolymers and the secondary component (biopolymers as complements, additives, or nano-scale biomaterials) to develop biocomposites.

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Series: Composites. Part B, Engineering
ISSN: 1359-8368
ISSN-E: 1879-1069
ISSN-L: 1359-8368
Volume: 258
Article number: 110701
DOI: 10.1016/j.compositesb.2023.110701
Type of Publication: A1 Journal article – refereed
Field of Science: 217 Medical engineering
216 Materials engineering
Funding: Justyna Kucinska-Lipka from Department of Polymer Technology, Faculty of Chemistry, Gdańsk University of Technology would like to acknowledge financial support provided to this research under the IDUB GUT RADIUM LEARNING THROUGH RESEARCH PROGRAMS number 12/Radium/2021. Tairong Kuang from College of Materials Science and Engineering, Zhejiang University of Technology would like to acknowledge financial support of National Natural Science Foundation of China (No. 52173046) and Ningbo Scientific and Technological Innovation 2025 Major Project (No. 2020Z097).
Copyright information: © 2023 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (