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Elabasy, A., Suhonen, M., Rajna, Z. et al. Respiratory brain impulse propagation in focal epilepsy. Sci Rep 13, 5222 (2023). https://doi.org/10.1038/s41598-023-32271-7

Respiratory brain impulse propagation in focal epilepsy

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Author: Elabasy, Ahmed1,2; Suhonen, Mia3,2; Rajna, Zalan1,2;
Organizations: 1Center for Machine Vision and Signal Analysis, University of Oulu, 90014, Oulu, Finland
2Oulu Functional NeuroImaging, Research Unit of Health Science and Technology, University of Oulu, 90029, Oulu, Finland
3Diagnostics, Medical Research Center, Oulu University Hospital, 90029, Oulu, Finland
4Clinical Neurophysiology, Research Unit of Health Science and Technology, University of Oulu, 90029, Oulu, Finland
5Research Unit of Clinical Neuroscience, Neurology, University of Oulu, 90029, Oulu, Finland
6Neurocenter (Member of ERN EpiCARE), Medical Research Center, Oulu University Hospital, 90029, Oulu, Finland
7Biocenter Oulu, University of Oulu, 90014, Oulu, Finland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 5.1 MB)
Persistent link: http://urn.fi/urn:nbn:fi-fe2023081696914
Language: English
Published: Springer Nature, 2023
Publish Date: 2023-08-16
Description:

Abstract

Respiratory brain pulsations pertaining to intra-axial hydrodynamic solute transport are markedly altered in focal epilepsy. We used optical flow analysis of ultra-fast functional magnetic resonance imaging (fMRI) data to investigate the velocity characteristics of respiratory brain impulse propagation in patients with focal epilepsy treated with antiseizure medication (ASM) (medicated patients with focal epilepsy; ME, n = 23), drug-naïve patients with at least one seizure (DN, n = 19) and matched healthy control subjects (HC, n = 75). We detected in the two patient groups (ME and DN) several significant alterations in the respiratory brain pulsation propagation velocity, which showed a bidirectional change dominated by a reduction in speed. Furthermore, the respiratory impulses moved more in reversed or incoherent directions in both patient groups vs. the HC group. The speed reductions and directionality changes occurred in specific phases of the respiratory cycle. In conclusion, irrespective of medication status, both patient groups showed incoherent and slower respiratory brain impulses, which may contribute to epileptic brain pathology by hindering brain hydrodynamics.

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Series: Scientific reports
ISSN: 2045-2322
ISSN-E: 2045-2322
ISSN-L: 2045-2322
Volume: 13
Issue: 1
Article number: 5222
DOI: 10.1038/s41598-023-32271-7
OADOI: https://oadoi.org/10.1038/s41598-023-32271-7
Type of Publication: A1 Journal article – refereed
Field of Science: 217 Medical engineering
Subjects:
Article
Funding: This work was supported by grants from the Finnish Academy grants 275352, 314497, 335720, 338599 (VKi), Jane and Aatos Erkko Foundation grants 1 & 210043 (VKi), KEVO grants from Oulu University Hospital (VKi), Epilepsy Research Foundation (JK), Finnish Cultural Foundation, North Ostrobothnia Regional Fund (JK), Tauno Tönning Foundation (JK, VKo), The University of Oulu Scholarship Foundation (JK), Medical Research Center (MRC) -Oulu (JK), Maire Taponen Foundation sr (JK), Finnish Brain Foundation sr (VKi, JK), Instrumentarium Science Foundation sr (JK), Orion Research Foundation (JK), The Finnish Medical Foundation (JK), and Pohjois-Suomen Terveydenhuollon tukisäätiö (VKo). The authors wish to acknowledge CSC – IT Center for Science, Finland, for computational resources.
Academy of Finland Grant Number: 275352
314497
335720
338599
Detailed Information: 275352 (Academy of Finland Funding decision)
314497 (Academy of Finland Funding decision)
335720 (Academy of Finland Funding decision)
338599 (Academy of Finland Funding decision)
Copyright information: © The Author(s) 2023, corrected publication 2023. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
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