University of Oulu

Majuri, T., Haapea, M., Nordström, T. et al. Effect of onset age on the long-term outcome of early-onset psychoses and other mental disorders: a register-based Northern Finland Birth Cohort 1986 study. Eur Child Adolesc Psychiatry (2023).

Effect of onset age on the long-term outcome of early-onset psychoses and other mental disorders : a register-based Northern Finland Birth Cohort 1986 study

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Author: Majuri, Tuomas1; Haapea, Marianne1,2,3; Nordström, Tanja1,2,4;
Organizations: 1Research Unit of Population Health, Faculty of Medicine, University of Oulu, P.O.BOX 5000, 90014, Oulu, Finland
2Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland
3Department of Psychiatry, Oulu University Hospital, Oulu, Finland
4Infrastructure for Population Studies, Northern Finland Birth Cohorts, University of Oulu, Arctic Biobank, Oulu, Finland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 0.6 MB)
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Language: English
Published: Springer Nature, 2023
Publish Date: 2023-08-18


Psychiatric illnesses can affect the social transitions of adolescence and young adulthood, such as completing education and entering working life and relationships. However, associations between earlier onset age and long-term outcomes among those with early-onset psychoses (EOP) are unclear, as are the long-term outcomes of EOP compared to non-psychotic disorders. We used national register data of the Northern Finland Birth Cohort 1986 to detect persons with EOP and other early-onset psychiatric disorders. The long-term clinical and work-family outcomes of persons with onset age before 18 years (n = 41 psychoses, n = 495 non-psychoses) or between 18–22 years (n = 61 psychoses, n = 377 non-psychoses) were compared. Individuals with the onset of psychosis between 18–22 years had significantly more unfavourable long-term outcomes when compared to those with psychosis onset before 18 years. Persons with psychosis onset before the age of 18 years had similar outcomes to those with non-psychotic psychiatric disorder onset before 18 years regarding educational level, marital status, having children, and substance use disorders. Individuals with EOP were more often on a disability pension compared to those with other early-onset mental disorders. Adjusting for sex, educational level and substance use only slightly diluted these results. Unexpectedly, later onset age of EOP was associated with worse outcomes. Those with psychosis onset between 18–22 years of age are in a critical period, which underlines the importance of investing on interventions in this age group. Further studies on the effect of the onset age on later outcomes in EOP are needed.

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Series: European child & adolescent psychiatry
ISSN: 1018-8827
ISSN-E: 1435-165X
ISSN-L: 1018-8827
Volume: Online first
DOI: 10.1007/s00787-023-02279-5
Type of Publication: A1 Journal article – refereed
Field of Science: 3124 Neurology and psychiatry
Funding: Open Access funding provided by University of Oulu including Oulu University Hospital. The NFBC1986 project is funded by EU QLG1-CT-2000–01643 (EUROBLCS) Grant no. E51560, NorFA Grant no. 731, 20056, 30167, USA/NIH 2000 G DF682 Grant no. 50945. T.M. received funding from the Finnish Medical Foundation, the University of Oulu Scholarship Foundation, the Finnish Psychiatric Research Foundation, and Oulu University Hospital (EVO Funding). J.M. received funding from the Juho Vainio Foundation and the Yrjö Jahnsson Foundation. E.J. received funding from the Academy of Finland (grant number 316563).
Academy of Finland Grant Number: 316563
Detailed Information: 316563 (Academy of Finland Funding decision)
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