Backström, M., Salo, H., Kärki, J. et al. The feasibility of existing JADAS10 cut-off values in clinical practice: a study of data from The Finnish Rheumatology Quality Register. Pediatr Rheumatol 21, 35 (2023). https://doi.org/10.1186/s12969-023-00814-x
The feasibility of existing JADAS10 cut-off values in clinical practice : a study of data from The Finnish Rheumatology Quality Register
|Author:||Backström, M.1,2,3; Salo, H.4; Kärki, J.5,6;|
1Department of Paediatrics, The Wellbeing Services County of Ostrobothnia, Vaasa, Finland
2PEDEGO Research Unit, University of Oulu, Oulu, Finland
3Vaasa Central Hospital, U2, Hietalahdenkatu 2-4, 65130, Vaasa, Finland
4Knowledge Brokers Department, Finnish Institute for Health and Welfare, Helsinki, Finland
5Department of Children and Adolescents, Kanta-Häme Central Hospital, Hämeenlinna, Finland
6The Finnish Institute for Welfare and Health, The Finnish Rheumatology Quality Register, Helsinki, Finland
7New Children’s Hospital, Pediatric Research Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland
8Department of Paediatrics, Turku University Hospital, Turku, Finland
9Department of Children and Adolescents, Kuopio University Hospital, Kuopio, Finland
10Department of Children and Adolescents, Päijät-Häme Central Hospital, Lahti, Finland
11Department of Paediatrics, Central Ostrobothnia Central Hospital, Kokkola, Finland
12Centre for Rheumatology and Clinical Immunology, Division of Medicine, University of Turku and Turku University Hospital, Turku, Finland
13Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland
14Centre for Rheumatic Diseases, Tampere University Hospital, Tampere, Finland
15Centre for Rheumatic Diseases, Kanta-Häme Central Hospital, Hämeenlinna, Finland
16Division of Rheumatology, Kuopio University Hospital, Kuopio, Finland
17Department of Rheumatology, Inflammation Center, Helsinki University Hospital, and University of Helsinki, Helsinki, Finland
18Department of Internal Medicine, Oulu University Hospital, Oulu, Finland
19Department of Biostatistics, University of Turku, Turku, Finland
20University of Eastern Finland, Kuopio and Central Finland Central Hospital, Jyväskylä, Finland
21Department of Paediatrics, Oulu University Hospital, Oulu, Finland
22Medical Research Center, Oulu University Hospital and University of Oulu, Oulu, Finland
|Online Access:||PDF Full Text (PDF, 1.1 MB)|
|Persistent link:|| http://urn.fi/urn:nbn:fi-fe20230823103656
|Publish Date:|| 2023-08-23
Background: The ten-joint juvenile arthritis disease activity score (JADAS10) is designed to measure the level of disease activity in non-systemic juvenile idiopathic arthritis by providing a single numeric score. The clinical JADAS10 (cJADAS10) is a modification of the JADAS10 that excludes erythrocyte sedimentation rate (ESR). Three different sets of JADAS10/cJADAS10 cut-offs for disease activity states have been published, i.e., the Backström, Consolaro, and Trincianti cut-offs. The objective of this study was to investigate the performance of existing JADAS10 cut-offs in real-life settings using patient data from The Finnish Rheumatology Quality Register (FinRheuma).
Methods: Data were collected from the FinRheuma register. The proportion of patients with an active joint count (AJC) above zero when classified as being in clinically inactive disease (CID) or low disease activity (LDA) groups according to existing JADAS10/cJADAS10 cut-off levels were analyzed.
Results: A significantly larger proportion of the patients classified as being in CID had an AJC > 0 when using the JADAS10/cJADAS10 cut-offs by Trincianti et al. compared to those for the other cut-offs. In the LDA group, a significantly larger proportion of the polyarticular patients (35%/29%) had an AJC of two when Trincianti JADAS10/cJADAS10 cut-offs were used compared with when Backström (11%/10%) and Consolaro (7%/3%) JADAS10/cJADAS10 cut-offs were used.
Conclusions: We found the cut-offs proposed by Consolaro et al. to be the most feasible, since these cut-off levels for CID do not result in the misclassification of active disease as remission, and the proportion of patients with AJC > 1 in the LDA group is lowest using these cut-offs.
|Type of Publication:||
A1 Journal article – refereed
|Field of Science:||
3123 Gynaecology and paediatrics
This work was supported by State funding for university-level health research, Vaasa Central Hospital, Finland to M.B.; State funding for university-level health research Oulu University Hospital, Finland to P.V.; The Finnish Cultural Foundation, Finland to P.V.; Maire Lisko säätiö, Finland to M.B.; The Finnish Medical Foundation grant number 4947 to M.B.
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