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The feasibility of existing JADAS10 cut-off values in clinical practice : a study of data from The Finnish Rheumatology Quality Register |
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| Author: | Backström, M.1,2,3; Salo, H.4; Kärki, J.5,6; |
| Organizations: |
1Department of Paediatrics, The Wellbeing Services County of Ostrobothnia, Vaasa, Finland 2PEDEGO Research Unit, University of Oulu, Oulu, Finland 3Vaasa Central Hospital, U2, Hietalahdenkatu 2-4, 65130, Vaasa, Finland
4Knowledge Brokers Department, Finnish Institute for Health and Welfare, Helsinki, Finland
5Department of Children and Adolescents, Kanta-Häme Central Hospital, Hämeenlinna, Finland 6The Finnish Institute for Welfare and Health, The Finnish Rheumatology Quality Register, Helsinki, Finland 7New Children’s Hospital, Pediatric Research Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland 8Department of Paediatrics, Turku University Hospital, Turku, Finland 9Department of Children and Adolescents, Kuopio University Hospital, Kuopio, Finland 10Department of Children and Adolescents, Päijät-Häme Central Hospital, Lahti, Finland 11Department of Paediatrics, Central Ostrobothnia Central Hospital, Kokkola, Finland 12Centre for Rheumatology and Clinical Immunology, Division of Medicine, University of Turku and Turku University Hospital, Turku, Finland 13Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland 14Centre for Rheumatic Diseases, Tampere University Hospital, Tampere, Finland 15Centre for Rheumatic Diseases, Kanta-Häme Central Hospital, Hämeenlinna, Finland 16Division of Rheumatology, Kuopio University Hospital, Kuopio, Finland 17Department of Rheumatology, Inflammation Center, Helsinki University Hospital, and University of Helsinki, Helsinki, Finland 18Department of Internal Medicine, Oulu University Hospital, Oulu, Finland 19Department of Biostatistics, University of Turku, Turku, Finland 20University of Eastern Finland, Kuopio and Central Finland Central Hospital, Jyväskylä, Finland 21Department of Paediatrics, Oulu University Hospital, Oulu, Finland 22Medical Research Center, Oulu University Hospital and University of Oulu, Oulu, Finland |
| Format: | article |
| Version: | published version |
| Access: | open |
| Online Access: | PDF Full Text (PDF, 1.1 MB) |
| Persistent link: | http://urn.fi/urn:nbn:fi-fe20230823103656 |
| Language: | English |
| Published: |
Springer Nature,
2023
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| Publish Date: | 2023-08-23 |
| Description: |
AbstractBackground: The ten-joint juvenile arthritis disease activity score (JADAS10) is designed to measure the level of disease activity in non-systemic juvenile idiopathic arthritis by providing a single numeric score. The clinical JADAS10 (cJADAS10) is a modification of the JADAS10 that excludes erythrocyte sedimentation rate (ESR). Three different sets of JADAS10/cJADAS10 cut-offs for disease activity states have been published, i.e., the Backström, Consolaro, and Trincianti cut-offs. The objective of this study was to investigate the performance of existing JADAS10 cut-offs in real-life settings using patient data from The Finnish Rheumatology Quality Register (FinRheuma). Methods: Data were collected from the FinRheuma register. The proportion of patients with an active joint count (AJC) above zero when classified as being in clinically inactive disease (CID) or low disease activity (LDA) groups according to existing JADAS10/cJADAS10 cut-off levels were analyzed. Results: A significantly larger proportion of the patients classified as being in CID had an AJC > 0 when using the JADAS10/cJADAS10 cut-offs by Trincianti et al. compared to those for the other cut-offs. In the LDA group, a significantly larger proportion of the polyarticular patients (35%/29%) had an AJC of two when Trincianti JADAS10/cJADAS10 cut-offs were used compared with when Backström (11%/10%) and Consolaro (7%/3%) JADAS10/cJADAS10 cut-offs were used. Conclusions: We found the cut-offs proposed by Consolaro et al. to be the most feasible, since these cut-off levels for CID do not result in the misclassification of active disease as remission, and the proportion of patients with AJC > 1 in the LDA group is lowest using these cut-offs. see all
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| Series: |
Pediatric rheumatology |
| ISSN: | 1546-0096 |
| ISSN-E: | 1546-0096 |
| ISSN-L: | 1546-0096 |
| Volume: | 21 |
| Issue: | 1 |
| Article number: | 35 |
| DOI: | 10.1186/s12969-023-00814-x |
| OADOI: | https://oadoi.org/10.1186/s12969-023-00814-x |
| Type of Publication: |
A1 Journal article – refereed |
| Field of Science: |
3123 Gynaecology and paediatrics |
| Subjects: | |
| Funding: |
This work was supported by State funding for university-level health research, Vaasa Central Hospital, Finland to M.B.; State funding for university-level health research Oulu University Hospital, Finland to P.V.; The Finnish Cultural Foundation, Finland to P.V.; Maire Lisko säätiö, Finland to M.B.; The Finnish Medical Foundation grant number 4947 to M.B. |
| Copyright information: |
© The Author(s) 2023. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
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https://creativecommons.org/licenses/by/4.0/ |