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Dementia prevention : the potential long-term cost-effectiveness of the FINGER prevention program |
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| Author: | Wimo, Anders1; Handels, Ron1,2; Antikainen, Riitta3; |
| Organizations: |
1Department of NVS, Centre of Alzheimer Research, Division of Neurogeriatrics, Karolinska Institutet, Stockholm, Sweden 2Deperatment of Psychiatry and Neuropsychology, Maastricht University, Alzheimer Centre Limburg, School for Mental Health and Neurosciences, Maastricht, the Netherlands 3Center for Life Course Health Research/Geriatrics, University of Oulu, Medical Research Center, Oulu University Hospital, Oulu, Finland
4Department of NVS, Centre of Alzheimer Research, Division of Clinical Geriatrics Karolinska Institutet, Stockholm, Sweden
5Theme Inflammation and Aging, Karolinska University Hospital, Stockholm, Sweden 6Care Policy and Evaluation Centre, Department of Health Policy, London School of Economics and Political Science, London, UK 7Faculty of Social Sciences (Health Sciences) and Gerontology Research Center (GEREC), Tampere University, Tampere, Finland 8Division of Clinical Geriatrics, Center for Alzheimer Research, NVS, Karolinska Institutet, Stockholm, Sweden 9Population Health Unit, Finnish Institute for Health and Welfare, Helsinki, Finland 10Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland 11Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland 12Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland 13Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden 14Institute of Clinical Medicine, Neurology, University of Eastern Finland, Kuopio, Finland 15Population Health Promotion Unit, Finnish Institute for Health and Welfare, Helsinki, Finland 16Department of Public Health, University of Helsinki, Helsinki, Finland 17National School of Public Health, Madrid, Spain 18Public Health Promotion Unit, National Institute for Health and Welfare, Helsinki, Finland 19South Ostrobothnia Central Hospital, Seinäjoki, Finland 20Diabetes Research Group, King Abdulaziz University, Jeddah, Saudi Arabia 21Division of Clinical Geriatrics, NVS, Karolinska Institutet, Stockholm, Sweden 22Ageing Epidemiology Research Unit, School of Public Health, Imperial College London, London, UK |
| Format: | article |
| Version: | published version |
| Access: | open |
| Online Access: | PDF Full Text (PDF, 0.3 MB) |
| Persistent link: | http://urn.fi/urn:nbn:fi-fe20230825107893 |
| Language: | English |
| Published: |
Elsevier,
2023
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| Publish Date: | 2023-08-25 |
| Description: |
AbstractIntroduction: The aim of this study was to estimate the potential cost-effectiveness of the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) program. Methods: A life-time Markov model with societal perspective, simulating a cohort of people at risk of dementia reflecting usual care and the FINGER program. Results: Costs were 1,653,275 and 1,635,346 SEK and quality-adjusted life years (QALYs) were 8.636 and 8.679 for usual care and the FINGER program, respectively, resulting in savings of 16,928 SEK (2023 US$) and 0.043 QALY gains per person, supporting extended dominance for the FINGER program. A total of 1623 dementia cases were avoided with 0.17 fewer person-years living with dementia. The sensitivity analysis confirmed the conclusions in most scenarios. Discussion: The model provides support that programs like FINGER have the potential to be cost-effective in preventing dementia. Results at the individual level are rather modest, but the societal benefits can be substantial because of the large potential target population. see all
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| Series: |
Alzheimer's & dementia. The journal of the Alzheimer's Association |
| ISSN: | 1552-5260 |
| ISSN-E: | 1552-5279 |
| ISSN-L: | 1552-5260 |
| Volume: | 19 |
| Issue: | 3 |
| Pages: | 999 - 1008 |
| DOI: | 10.1002/alz.12698 |
| OADOI: | https://oadoi.org/10.1002/alz.12698 |
| Type of Publication: |
A1 Journal article – refereed |
| Field of Science: |
3112 Neurosciences 3124 Neurology and psychiatry |
| Subjects: | |
| Funding: |
The work was conducted as part of the EU Joint Programme – Neurodegenerative Disease Research (JPND) projects MIND-AD and EURO-FINGERS. The project is additionally supported by Alzheimerfonden, Center for Innovative Medicine (CIMED) at Karolinska Institutet South Campus, the Konung Gustaf V:s och Drottning Victorias Frimurarestiftelse, Region Stockholm (ALF, NSV), Stiftelsen Stockholms sjukhem, Swedish Research Council for Health Working Life and Welfare (FORTE), and European Research Council grant 804371, Academy of Finland (grants 317465, 287490, 294061, 319318), Finnish Social Insurance Institution, Finnish Ministry of Education and Culture, Juho Vainio Foundation, Finland, Alzheimer's Research and Prevention Foundation, US. |
| Copyright information: |
© 2022 The Authors. Alzheimer’s & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer’s Association. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
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https://creativecommons.org/licenses/by-nc-nd/4.0/ |