University of Oulu

Wimo, A, Handels, R, Antikainen, R, et al. Dementia prevention: The potential long-term cost-effectiveness of the FINGER prevention program. Alzheimer's Dement. 2023; 19: 999–1008.

Dementia prevention : the potential long-term cost-effectiveness of the FINGER prevention program

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Author: Wimo, Anders1; Handels, Ron1,2; Antikainen, Riitta3;
Organizations: 1Department of NVS, Centre of Alzheimer Research, Division of Neurogeriatrics, Karolinska Institutet, Stockholm, Sweden
2Deperatment of Psychiatry and Neuropsychology, Maastricht University, Alzheimer Centre Limburg, School for Mental Health and Neurosciences, Maastricht, the Netherlands
3Center for Life Course Health Research/Geriatrics, University of Oulu, Medical Research Center, Oulu University Hospital, Oulu, Finland
4Department of NVS, Centre of Alzheimer Research, Division of Clinical Geriatrics Karolinska Institutet, Stockholm, Sweden
5Theme Inflammation and Aging, Karolinska University Hospital, Stockholm, Sweden
6Care Policy and Evaluation Centre, Department of Health Policy, London School of Economics and Political Science, London, UK
7Faculty of Social Sciences (Health Sciences) and Gerontology Research Center (GEREC), Tampere University, Tampere, Finland
8Division of Clinical Geriatrics, Center for Alzheimer Research, NVS, Karolinska Institutet, Stockholm, Sweden
9Population Health Unit, Finnish Institute for Health and Welfare, Helsinki, Finland
10Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland
11Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland
12Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland
13Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden
14Institute of Clinical Medicine, Neurology, University of Eastern Finland, Kuopio, Finland
15Population Health Promotion Unit, Finnish Institute for Health and Welfare, Helsinki, Finland
16Department of Public Health, University of Helsinki, Helsinki, Finland
17National School of Public Health, Madrid, Spain
18Public Health Promotion Unit, National Institute for Health and Welfare, Helsinki, Finland
19South Ostrobothnia Central Hospital, Seinäjoki, Finland
20Diabetes Research Group, King Abdulaziz University, Jeddah, Saudi Arabia
21Division of Clinical Geriatrics, NVS, Karolinska Institutet, Stockholm, Sweden
22Ageing Epidemiology Research Unit, School of Public Health, Imperial College London, London, UK
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 0.3 MB)
Persistent link:
Language: English
Published: Elsevier, 2023
Publish Date: 2023-08-25


Introduction: The aim of this study was to estimate the potential cost-effectiveness of the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) program.

Methods: A life-time Markov model with societal perspective, simulating a cohort of people at risk of dementia reflecting usual care and the FINGER program.

Results: Costs were 1,653,275 and 1,635,346 SEK and quality-adjusted life years (QALYs) were 8.636 and 8.679 for usual care and the FINGER program, respectively, resulting in savings of 16,928 SEK (2023 US$) and 0.043 QALY gains per person, supporting extended dominance for the FINGER program. A total of 1623 dementia cases were avoided with 0.17 fewer person-years living with dementia. The sensitivity analysis confirmed the conclusions in most scenarios.

Discussion: The model provides support that programs like FINGER have the potential to be cost-effective in preventing dementia. Results at the individual level are rather modest, but the societal benefits can be substantial because of the large potential target population.

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Series: Alzheimer's & dementia. The journal of the Alzheimer's Association
ISSN: 1552-5260
ISSN-E: 1552-5279
ISSN-L: 1552-5260
Volume: 19
Issue: 3
Pages: 999 - 1008
DOI: 10.1002/alz.12698
Type of Publication: A1 Journal article – refereed
Field of Science: 3112 Neurosciences
3124 Neurology and psychiatry
Funding: The work was conducted as part of the EU Joint Programme – Neurodegenerative Disease Research (JPND) projects MIND-AD and EURO-FINGERS. The project is additionally supported by Alzheimerfonden, Center for Innovative Medicine (CIMED) at Karolinska Institutet South Campus, the Konung Gustaf V:s och Drottning Victorias Frimurarestiftelse, Region Stockholm (ALF, NSV), Stiftelsen Stockholms sjukhem, Swedish Research Council for Health Working Life and Welfare (FORTE), and European Research Council grant 804371, Academy of Finland (grants 317465, 287490, 294061, 319318), Finnish Social Insurance Institution, Finnish Ministry of Education and Culture, Juho Vainio Foundation, Finland, Alzheimer's Research and Prevention Foundation, US.
Copyright information: © 2022 The Authors. Alzheimer’s & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer’s Association. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.