University of Oulu

Farrahi V, Rostami M, Nauha L, et al. Replacing sedentary time with physical activity and sleep: Associations with cardiometabolic health markers in adults. Scand J Med Sci Sports. 2023;33:907-920. doi:10.1111/sms.14323

Replacing sedentary time with physical activity and sleep : associations with cardiometabolic health markers in adults

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Author: Farrahi, Vahid1,2; Rostami, Mehrdad2; Nauha, Lauri1,3;
Organizations: 1Research Unit of Health Sciences and Technology, Faculty of Medicine, University of Oulu, Oulu, Finland
2Center of Machine Vision and Signal Analysis, Faculty of Information Technology, University of Oulu, Oulu, Finland
3Research Unit of Population Health, Faculty of Medicine, University of Oulu, Oulu, Finland
4Geography Research Unit, Faculty of Science, University of Oulu, Oulu, Finland
5Medical Research Center, Oulu University Hospital and University of Oulu, Oulu, Finland
6Department of Sports and Exercise Medicine, Oulu Deaconess Institute Foundation sr., Oulu, Finland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 0.9 MB)
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Language: English
Published: John Wiley & Sons, 2023
Publish Date: 2023-09-01


This study aimed to examine the associations of sedentary time, and substituting sedentary time with physical activity and sleep, with cardiometabolic health markers while accounting for a full 24 h of movement and non-movement behaviors, cardiorespiratory fitness (CRF), and other potential confounders. The participants were 4585 members of the Northern Finland Birth Cohort 1966, who wore a hip-worn accelerometer at the age of 46 years for 14 consecutive days. Time spent in sedentary behaviors, light-intensity physical activity (LPA), and moderate-to-vigorous-intensity physical activity (MVPA) were determined from the accelerometer and combined with self-reported sleep duration to obtain the 24-h time use. CRF was estimated from the peak heart rate in a submaximal step test. An isotemporal substitution paradigm was used to examine how sedentary time and substituting sedentary time with an equal amount of LPA, MVPA, or sleep were associated with adiposity markers, blood lipid levels, and fasting glucose and insulin. Sedentary time was independently and adversely associated with the markers of cardiometabolic health, even after adjustment for CRF, but not in partition models including LPA, MVPA, sleep, and CRF. Substituting 60, 45, 30, and 15 min/day of sedentary time with LPA or MVPA was associated with 0.2%–13.7% favorable differences in the cardiometabolic health markers after accounting for LPA, MVPA, sleep, CRF, and other confounders. After adjustment for movement and non-movement behaviors within the 24-h cycle, reallocating additional time to both LPA and MVPA was beneficially associated with markers of cardiometabolic health in middle-aged adults regardless of their CRF level.

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Series: Scandinavian journal of medicine & science in sports
ISSN: 0905-7188
ISSN-E: 1600-0838
ISSN-L: 0905-7188
Volume: 33
Issue: 6
Pages: 907 - 920
DOI: 10.1111/sms.14323
Type of Publication: A1 Journal article – refereed
Field of Science: 3142 Public health care science, environmental and occupational health
Funding: This study is connected to the DigiHealth-project, a strategic profiling project at the University of Oulu. The project is supported by the Academy of Finland (project number 326291) and the University of Oulu. This study has also received funding from the Ministry of Education and Culture in Finland (grant numbers OKM/20/626/2022, OKM/1096/626/2020, OKM/88/626/2019, OKM/85/626/2019, OKM/54/626/2019, OKM/78/626/2018, and OKM 47/626/2017). NFBC1966 received financial support from University of Oulu Grant no. 24000692, Oulu University Hospital Grant no. 24301140, ERDF European Regional Development Fund Grant no. 539/2010 A31592. The funders played no role in designing the study, or collecting, analyzing, and interpreting the data, or writing the article.
Dataset Reference: The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available due to privacy or ethical restrictions.
Copyright information: © 2023 The Authors. Scandinavian Journal of Medicine & Science In Sports published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.