Urbiola-Salvador V, Jabłońska A, Miroszewska D, Huang Q, Duzowska K, Drężek-Chyła K, Zdrenka M, Śrutek E, Szylberg Ł, Jankowski M, Bała D, Zegarski W, Nowikiewicz T, Makarewicz W, Adamczyk A, Ambicka A, Przewoźnik M, Harazin-Lechowicz A, Ryś J, Filipowicz N, Piotrowski A, Dumanski JP, Li B and Chen Z (2023) Plasma protein changes reflect colorectal cancer development and associated inflammation. Front. Oncol. 13:1158261. doi: 10.3389/fonc.2023.1158261
Plasma protein changes reflect colorectal cancer development and associated inflammation
|Author:||Urbiola-Salvador, Víctor1; Jabłońska, Agnieszka1; Miroszewska, Dominika1;|
1Intercollegiate Faculty of Biotechnology of University of Gdańsk and Medical University of Gdańsk, University of Gdańsk, Gdańsk, Poland
2Center for Immune-Related Diseases at Shanghai Institute of Immunology, Department of Respiratory and Critical Care Medicine of Ruijin Hospital, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China
33P-Medicine Laboratory, Medical University of Gdańsk, Gdańsk, Poland
4Department of Tumor Pathology and Pathomorphology, Oncology Center−Prof. Franciszek Łukaszczyk Memorial Hospital, Bydgoszcz, Poland
5Department of Obstetrics, Gynaecology and Oncology, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Bydgoszcz, Poland
6Surgical Oncology, Ludwik Rydygier’s Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in ToruńSurgical Oncology, Ludwik Rydygier’s Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Toruń, Poland
7Department of Surgical Oncology, Oncology Center−Prof. Franciszek Łukaszczyk Memorial Hospital, Bydgoszcz, Poland
8Department of Breast Cancer and Reconstructive Surgery, Oncology Center−Prof. Franciszek Łukaszczyk Memorial Hospital, Bydgoszcz, Poland
9Clinic of General and Oncological Surgery, Specialist Hospital of Kościerzyna, Kościerzyna, Poland
10Department of Tumor Pathology, Maria Skłodowska-Curie National Research Institute of Oncology, Kraków, Poland
11Department of Immunology, Genetics and Pathology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden
12Department of Biology and Pharmaceutical Botany, Medical University of Gdańsk, Gdańsk, Poland
13Faculty of Biochemistry and Molecular Medicine, University of Oulu, Oulu, Finland
|Online Access:||PDF Full Text (PDF, 4.1 MB)|
|Persistent link:|| http://urn.fi/urn:nbn:fi-fe20230906120190
|Publish Date:|| 2023-09-06
Introduction: Colorectal cancer (CRC) is the third most common malignancy and the second leading cause of death worldwide. Efficient non-invasive blood-based biomarkers for CRC early detection and prognosis are urgently needed.
Methods: To identify novel potential plasma biomarkers, we applied a proximity extension assay (PEA), an antibody-based proteomics strategy to quantify the abundance of plasma proteins in CRC development and cancer-associated inflammation from few μL of plasma sample.
Results: Among the 690 quantified proteins, levels of 202 plasma proteins were significantly changed in CRC patients compared to age-and-sex-matched healthy subjects. We identified novel protein changes involved in Th17 activity, oncogenic pathways, and cancer-related inflammation with potential implications in the CRC diagnosis. Moreover, the interferon γ (IFNG), interleukin (IL) 32, and IL17C were identified as associated with the early stages of CRC, whereas lysophosphatidic acid phosphatase type 6 (ACP6), Fms-related tyrosine kinase 4 (FLT4), and MANSC domain-containing protein 1 (MANSC1) were correlated with the late-stages of CRC.
Discussion: Further study to characterize the newly identified plasma protein changes from larger cohorts will facilitate the identification of potential novel diagnostic, prognostic biomarkers for CRC.
Frontiers in oncology
|Type of Publication:||
A1 Journal article – refereed
|Field of Science:||
This research was funded by the National Science Centre of Poland, grant number 2018/30/Q/NZ6/00769 (granted to ZC). The CRC sample collection from the Medical University of Gdansk was sponsored by the Foundation for Polish Science (FNP) under the International Research Agendas Program (granted to JPD and AP), co-financed by the European Union under the European Regional Development Fund and via the “Excellence Initiative - Research University” program from Medical University of Gdańsk and The Swedish Cancer Society (granted to JPD).
© 2023 Urbiola-Salvador, Jabłońska, Miroszewska, Huang, Duzowska, Drężek-Chyła, Zdrenka, Śrutek, Szylberg, Jankowski, Bała, Zegarski, Nowikiewicz, Makarewicz, Adamczyk, Ambicka, Przewoźnik, Harazin-Lechowicz, Ryś, Filipowicz, Piotrowski, Dumanski, Li and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.