University of Oulu

Avsievich T, Zhu R, Popov AP, Yatskovskiy A, Popov AA, Tikhonowsky G, Pastukhov AI, Klimentov S, Bykov A, Kabashin A, et al. Impact of Plasmonic Nanoparticles on Poikilocytosis and Microrheological Properties of Erythrocytes. Pharmaceutics. 2023; 15(4):1046.

Impact of plasmonic nanoparticles on poikilocytosis and microrheological properties of erythrocytes

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Author: Avsievich, Tatiana1; Zhu, Ruixue1; Popov, Alexey P.2;
Organizations: 1Optoelectronics and Measurement Techniques, University of Oulu, 90570 Oulu, Finland
2VTT Technical Research Centre of Finland, Kaitovayla 1, 90590 Oulu, Finland
3Department of Histology, Cytology and Embryology, Institute of Clinical Medicine N.V. Sklifosovsky, I.M. Sechenov First Moscow State Medical University, Trubetskaya Street 8, 119991 Moscow, Russia
4Institute of Engineering Physics for Biomedicine (PhysBio), National Research Nuclear University (MEPhI), Kashirskoe Shosse, 31, 115409 Moscow, Russia
5CNRS, LP3, Aix-Marseille University, 163 Av. de Luminy, 13009 Marseille, France
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 78 MB)
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Language: English
Published: Multidisciplinary Digital Publishing Institute, 2023
Publish Date: 2023-09-12


Plasmonic nanoparticles (NP) possess great potential in photothermal therapy and diagnostics. However, novel NP require a detailed examination for potential toxicity and peculiarities of interaction with cells. Red blood cells (RBC) are important for NP distribution and the development of hybrid RBC-NP delivery systems. This research explored RBC alterations induced by noble (Au and Ag) and nitride-based (TiN and ZrN) laser-synthesized plasmonic NP. Optical tweezers and conventional microscopy modalities indicated the effects arising at non-hemolytic levels, such as RBC poikilocytosis, and alterations in RBC microrheological parameters, elasticity and intercellular interactions. Aggregation and deformability significantly decreased for echinocytes independently of NP type, while for intact RBC, all NP except Ag NP increased the interaction forces but had no effect on RBC deformability. RBC poikilocytosis promoted by NP at concentration 50 μg mL⁻¹ was more pronounced for Au and Ag NP, compared to TiN and ZrN NP. Nitride-based NP demonstrated better biocompatibility towards RBC and higher photothermal efficiency than their noble metal counterparts.

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Series: Pharmaceutics
ISSN: 1999-4923
ISSN-E: 1999-4923
ISSN-L: 1999-4923
Volume: 15
Issue: 4
Article number: 1046
DOI: 10.3390/pharmaceutics15041046
Type of Publication: A1 Journal article – refereed
Field of Science: 213 Electronic, automation and communications engineering, electronics
Funding: Current study partially supported by the Suomen Kulttuurirahasto (grant No. 00190188), China Scholarship Council (CSC No. 201706410089) and the INFOTECH and the Academy of Finland (project 325097). The authors also acknowledge the contribution of Russian Science Foundation (Project: 19-72-30012 and Project: 22-65-00096). I.M. acknowledges the support from the Leverhulme Trust and The Royal Society (Ref. no.: APX\R1\211232 APEX Awards 2021).
Academy of Finland Grant Number: 325097
Detailed Information: 325097 (Academy of Finland Funding decision)
Copyright information: © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (