University of Oulu

Kujala, Emmi; Hakko, Helinä; Riipinen, Pirkko; Riala, Kaisa. Associations of adolescent psychosocial factors to later benzodiazepine use: a population-based follow-up study of adolescent psychiatric inpatients in Northern Finland. International Clinical Psychopharmacology 38(3):p 146-153, May 2023. | DOI: 10.1097/YIC.0000000000000441

Associations of adolescent psychosocial factors to later benzodiazepine use : a population-based follow-up study of adolescent psychiatric inpatients in Northern Finland

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Author: Kujala, Emmi1; Hakko, Helinä2; Riipinen, Pirkko1;
Organizations: 1Faculty of Medicine, Research Unit of Clinical Medicine, Psychiatry, University of Oulu
2Oulu University Hospital, Psychiatry, Oulu, Finland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 0.5 MB)
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Language: English
Published: Wolters Kluwer, 2023
Publish Date: 2023-09-22


We investigated factors associated with benzodiazepine (BZD) use during late adolescence and early adulthood. The study population consisted of 508 adolescents admitted to psychiatric inpatient care between April 2001 and March 2006. Information on adolescents’ family- and school-related factors, suicidality and psychiatric disorders were obtained by semistructured interviews. Data on BZD prescriptions from 1999 to 2012 were collected from the Social Insurance Institution of Finland. In males heavy BZD use associated with adolescent substance-use disorder (OR, 3.5; P < 0.004) and parents’ psychiatric problems (OR, 3.5; P = 0.029). Among females, conduct disorder (OR, 3.3; P = 0.016), being a bully/bully-victim (OR, 3.3; P = 0.019) and parental substance-use problems (OR, 2.6; P = 0.024) were related to heavy BZD use. The mean (±SD) age of first BZD prescription was significantly lower in heavy, compared with mild users (men: 19.3 ± 2.5 vs. 21.0 ± 2.5 years, P = 0.027; women: 19.7 ± 2.6 vs. 21.5 ± 3.4 years, P = 0.027). Heavy, compared with mild, BZD use is associated with female suicide attempts (OR, 5.0; P = 0.049). Physicians should be cautious when prescribing BZDs to young adults and must allocate treatment to those with carefully evaluated clinical indications.

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Series: International clinical psychopharmacology
ISSN: 0268-1315
ISSN-E: 1473-5857
ISSN-L: 0268-1315
Volume: 38
Issue: 3
Pages: 146 - 153
DOI: 10.1097/YIC.0000000000000441
Type of Publication: A1 Journal article – refereed
Field of Science: 3124 Neurology and psychiatry
Copyright information: © 2022 The Author(s). Published by Wolters Kluwer Health, Inc. This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.