University of Oulu

Martta Kerkelä, Mika Gissler, Tanja Nordström, Olavi Ukkola & Juha Veijola (2023) Association between participation in the Northern Finland Birth Cohorts and cardiometabolic disorders, Annals of Medicine, 55:1, 1123-1133, DOI:

Association between participation in the Northern Finland Birth Cohorts and cardiometabolic disorders

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Author: Kerkelä, Martta1; Gissler, Mika2,3,4,5; Nordström, Tanja6,7,8;
Organizations: 1Research Unit of Clinical Medicine, University of Oulu, Oulu, Finland
2Department of Knowledge Brokers, Finnish Institute for Healthand Welfare, Helsinki, Finland
3Research Centre for Child Psychiatry, University of Turku, Turku, Finland
4Academic Primary Health Care Centre, Region Stockholm, Sweden
5Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden
6Northern Finland Birth Cohorts, Arctic Biobank, Infrastructure for Population Studies, Faculty of Medicine, University of Oulu, Oulu, Finland
7Research Unit of Population Health, University of Oulu, Oulu, Finland
8Medical Research Center, University Hospital and University of Oulu, Oulu, Finland
9Research Unit of Internal Medicine, University of Oulu, Oulu, Finland
10Department of Psychiatry, University Hospital of Oulu, Oulu, Finland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 2.1 MB)
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Language: English
Published: Informa, 2023
Publish Date: 2023-09-25


Background: We studied the association between participation in the longitudinal follow-up study and cardiometabolic disorders in two longitudinal studies which started prospectively in the antenatal period: the Northern Finland Cohort 1966 (NFBC1966) and the Northern Finland Birth Cohort 1986 (NFBC1986). Both birth cohorts have been followed up since birth with multiple follow-ups including questionnaires, and clinical examinations.

Methods: The NFBC studies were compared to comparison cohorts of individuals who were born in the same area as the study cohorts, but in different years. The data for the comparison cohort were obtained from registers. The cumulative incidence rates of hospital-treated cardiometabolic disorders were calculated for study and comparison cohorts covering the age of 7–50 years in NFBC1966 and the age of 0–29 years in NFBC1986. Cardiometabolic-related causes of death were analysed in NFBC1966 and the comparison cohort from the age of 0–50 years. The analysed cardiometabolic disorders were diabetes mellitus, coronary artery disease, hyperlipidaemia, obesity, hypertension, and cerebrovascular disorders. The risk ratio (RR) with 95% confidence intervals (CI) was calculated by sex.

Results: In NFBC1966, no differences in cumulative incidences of cardiometabolic disorders or cardiometabolic-related deaths compared to the comparison cohort were found. Male members of NFBC1986 had decreased risk of obesity (RR: 0.45, 95% CI: 0.27–0.75) and any cardiometabolic disorders (RR: 0.75, 95% CI: 0.59–0.95) compared to the comparison cohort.

Conclusions: The results suggest that participation in the NFBC1986 may have a weak positive health effect among men. Agreement to follow-up studies focusing on diet, substance use, and physical activity, may slightly decrease the incident risk of cardiometabolic disorders in the study population.

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Series: Annals of medicine
ISSN: 0785-3890
ISSN-E: 1365-2060
ISSN-L: 0785-3890
Volume: 55
Issue: 1
Pages: 1123 - 1133
DOI: 10.1080/07853890.2023.2186478
Type of Publication: A1 Journal article – refereed
Field of Science: 3142 Public health care science, environmental and occupational health
Funding: NFBC1966 received financial support from University of Oulu Grant no. 65354, Oulu University Hospital Grant no. 2/97, 8/97, Ministry of Health and Social Affairs Grant no. 23/251/97, 160/97, 190/97, National Institute for Health and Welfare, Helsinki Grant no. 54121, Regional Institute of Occupational Health, Oulu, Finland Grant no. 50621, 54231. NFBC1986 received financial support from EU QLG1-CT-2000-01643 (EUROBLCS) Grant no. E51560, NorFA Grant no. 731, 20056, 30167 and USA/NIH 2000 G DF682 Grant no. 50945.
Copyright information: © 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.