University of Oulu

Elsayed, H., Karjalainen, J., Nissi, M. J., Ketola, J., Kajabi, A. W., Casula, V., Zbýň, Š., Nieminen, M. T., & Hanni, M. (2023). Assessing post-traumatic changes in cartilage using T1ρ dispersion parameters. In Magnetic Resonance Imaging (Vol. 97, pp. 91–101). Elsevier BV.

Assessing post-traumatic changes in cartilage using T dispersion parameters

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Author: Elsayed, Hassaan1,2; Karjalainen, Jouni1,2; Nissi, Mikko J.1,1;
Organizations: 1Research Unit of Health Sciences and Technology, Faculty of Medicine, University of Oulu, P.O.Box 5000, 90014 Oulu, Finland
2Medical Research Center Oulu, University of Oulu and Oulu University Hospital, Oulu, Finland
3Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, USA
4Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 3.7 MB)
Persistent link:
Language: English
Published: Elsevier, 2023
Publish Date: 2023-09-29


Degeneration of cartilage can be studied non-invasively with quantitative MRI. A promising parameter for detecting early osteoarthritis in articular cartilage is T, which can be tuned via the amplitude of the spin-lock pulse. By measuring T at several spin-lock amplitudes, the dispersion of Tis obtained. The aim of this study is to find out if the dispersion contains diagnostically relevant information complementary to a T measurement at a single spin-lock amplitude. To this end, five differently acquired dispersion parameters are utilized; A, B, τc, T/T2, and R2R. An open dataset of an equine model of post-traumatic cartilage was utilized to assess the T dispersion parameters for the evaluation of cartilage degeneration. Firstly, the parameters were compared for their sensitivity in detecting degenerative changes. Secondly, the relationship of the dispersion parameters to histological and biomechanical reference parameters was studied. Parameters A, T/T2, and R2R were found to be sensitive to lesion-induced changes in the cartilage within sample. Strong correlations of several dispersion parameters with optical density, as well as with collagen fibril angle were found. Most of the dispersion parameters correlated strongly with individual T values. The results suggest that dispersion parameters can in some cases provide a more accurate description of the biochemical composition of cartilage as compared to conventional MRI parameters. However, in most cases the information given by the dispersion parameters is more of a refinement than complementary to conventional quantitative MRI.

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Series: Magnetic resonance imaging
ISSN: 0730-725X
ISSN-E: 1873-5894
ISSN-L: 0730-725X
Volume: 97
Pages: 91 - 101
DOI: 10.1016/j.mri.2022.12.012
Type of Publication: A1 Journal article – refereed
Field of Science: 217 Medical engineering
Funding: This work was supported by Jane and Aatos Erkko foundation.
Copyright information: © 2023 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (