Elsayed, H., Karjalainen, J., Nissi, M. J., Ketola, J., Kajabi, A. W., Casula, V., Zbýň, Š., Nieminen, M. T., & Hanni, M. (2023). Assessing post-traumatic changes in cartilage using T1ρ dispersion parameters. In Magnetic Resonance Imaging (Vol. 97, pp. 91–101). Elsevier BV. https://doi.org/10.1016/j.mri.2022.12.012
Assessing post-traumatic changes in cartilage using T1ρ dispersion parameters
|Author:||Elsayed, Hassaan1,2; Karjalainen, Jouni1,2; Nissi, Mikko J.1,1;|
1Research Unit of Health Sciences and Technology, Faculty of Medicine, University of Oulu, P.O.Box 5000, 90014 Oulu, Finland
2Medical Research Center Oulu, University of Oulu and Oulu University Hospital, Oulu, Finland
3Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, USA
4Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland
|Online Access:||PDF Full Text (PDF, 3.7 MB)|
|Persistent link:|| http://urn.fi/urn:nbn:fi-fe20230929137818
|Publish Date:|| 2023-09-29
Degeneration of cartilage can be studied non-invasively with quantitative MRI. A promising parameter for detecting early osteoarthritis in articular cartilage is T1ρ, which can be tuned via the amplitude of the spin-lock pulse. By measuring T1ρ at several spin-lock amplitudes, the dispersion of T1ρis obtained. The aim of this study is to find out if the dispersion contains diagnostically relevant information complementary to a T1ρ measurement at a single spin-lock amplitude. To this end, five differently acquired dispersion parameters are utilized; A, B, τc, T1ρ/T2, and R2 − R1ρ. An open dataset of an equine model of post-traumatic cartilage was utilized to assess the T1ρ dispersion parameters for the evaluation of cartilage degeneration. Firstly, the parameters were compared for their sensitivity in detecting degenerative changes. Secondly, the relationship of the dispersion parameters to histological and biomechanical reference parameters was studied. Parameters A, T1ρ/T2, and R2 − R1ρ were found to be sensitive to lesion-induced changes in the cartilage within sample. Strong correlations of several dispersion parameters with optical density, as well as with collagen fibril angle were found. Most of the dispersion parameters correlated strongly with individual T1ρ values. The results suggest that dispersion parameters can in some cases provide a more accurate description of the biochemical composition of cartilage as compared to conventional MRI parameters. However, in most cases the information given by the dispersion parameters is more of a refinement than complementary to conventional quantitative MRI.
Magnetic resonance imaging
|Pages:||91 - 101|
|Type of Publication:||
A1 Journal article – refereed
|Field of Science:||
217 Medical engineering
This work was supported by Jane and Aatos Erkko foundation.
© 2023 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).