Abstract

Degeneration of cartilage can be studied non-invasively with quantitative MRI. A promising parameter for detecting early osteoarthritis in articular cartilage is T_1ρ, which can be tuned via the amplitude of the spin-lock pulse. By measuring T_1ρ at several spin-lock amplitudes, the dispersion of T_1ρis obtained. The aim of this study is to find out if the dispersion contains diagnostically relevant information complementary to a T_1ρ measurement at a single spin-lock amplitude. To this end, five differently acquired dispersion parameters are utilized; A, B, τc, T_1ρ/T₂, and R₂ − R_1ρ. An open dataset of an equine model of post-traumatic cartilage was utilized to assess the T_1ρ dispersion parameters for the evaluation of cartilage degeneration. Firstly, the parameters were compared for their sensitivity in detecting degenerative changes. Secondly, the relationship of the dispersion parameters to histological and biomechanical reference parameters was studied. Parameters A, T_1ρ/T₂, and R₂ − R_1ρ were found to be sensitive to lesion-induced changes in the cartilage within sample. Strong correlations of several dispersion parameters with optical density, as well as with collagen fibril angle were found. Most of the dispersion parameters correlated strongly with individual T_1ρ values. The results suggest that dispersion parameters can in some cases provide a more accurate description of the biochemical composition of cartilage as compared to conventional MRI parameters. However, in most cases the information given by the dispersion parameters is more of a refinement than complementary to conventional quantitative MRI.