Timo J. Autio, Timo Atula, Lauri Jouhi, Heikki Irjala, Elina Halme, Anna Jouppila-Mättö, Antti Mäkitie & Petri Koivunen (2023) Timing and frequency of oropharyngeal squamous cell carcinoma recurrences after treatment with curative intent, Acta Oto-Laryngologica, 143:4, 334-339, DOI: 10.1080/00016489.2023.2188892
Timing and frequency of oropharyngeal squamous cell carcinoma recurrences after treatment with curative intent
|Author:||Autio, Timo J.1,2,3; Atula, Timo4; Jouhi, Lauri4;|
1Department of Otorhinolaryngology and Head and Neck Surgery, Oulu University Hospital, Oulu, Finland
2PEDEGO Research Unit, University of Oulu, Oulu, Finland
3Medical Research Center Oulu, Oulu, Finland
4Department of Otorhinolaryngology - Head and Neck Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
5Department of Otorhinolaryngology and Head and Neck Surgery, Turku University Hospital and University of Turku, Turku, Finland
6Department of Otorhinolaryngology-Head and Neck Surgery, Tampere University Hospital, Tampere, Finland
7Department of Otorhinolaryngology- Head and Neck Surgery, Kuopio University Hospital, Kuopio, Finland
8Research Program in Systems Oncology, Faculty of Medicine, University of Helsinki, Helsinki, Finland
9Division of Ear, Nose and Throat Diseases, Department of Clinical Sciences, Intervention and Technology, Karolinska Institute and Karolinska University Hospital, Stockholm, Sweden
|Persistent link:|| http://urn.fi/urn:nbn:fi-fe20231003138518
|Publish Date:|| 2024-03-30
Background: The increasing number of patients under surveillance after treatment of human papillomavirus-related oropharyngeal squamous cell carcinoma (OPSCC) places a great burden on healthcare providers.
Aims/objectives: The aim of this study was to explore OPSCC recurrences in a long follow-up period: their site, frequency and timepoint after primary treatment, treatment and outcome. The secondary aim was to investigate if the recurrences are diagnosed on routine follow-up visits, and if the p16 status will have an effect on the pattern of recurrences.
Materials and methods: We analyzed recurrences within a 10-year follow-up period after completed curatively intended treatment among OPSCC patients in Finland treated between 2000 and 2009. Patient-, tumor-, treatment- and follow-up -related parameters were investigated.
Results: Out of 495 patients with no residual tumor during the first six months, 71 (14%) were diagnosed with a recurrence, of which 47 were locoregional and 28 were treated with curative intent. Of the recurrences, 86% were diagnosed during the first 36 months after primary treatment. Only ten recurrences appeared after 36 months. The median OS after recurrence was 10.9 months.
Conclusions: Routine follow-up longer than three years after treatment seems not to be effective in terms of detecting OPSCC recurrences.
|Pages:||328 - 333|
|Type of Publication:||
A1 Journal article – refereed
|Field of Science:||
3121 General medicine, internal medicine and other clinical medicine
This work was supported by Thelma Mäkikyrö foundation; HUS State Research Funding (TYH2021220).
This is an Accepted Manuscript version of the following article, accepted for publication in Acta Oto-Laryngologica. Timo J. Autio, Timo Atula, Lauri Jouhi, Heikki Irjala, Elina Halme, Anna Jouppila-Mättö, Antti Mäkitie & Petri Koivunen (2023) Timing and frequency of oropharyngeal squamous cell carcinoma recurrences after treatment with curative intent, Acta Oto-Laryngologica, 143:4, 334-339, DOI: 10.1080/00016489.2023.2188892. It is deposited under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited.