University of Oulu

Soppela, Helmi et al. ‘Traumatic Brain Injury Associates with an Earlier Onset in Sporadic Frontotemporal Dementia’. 1 Jan. 2023 : 225 – 232.

Traumatic brain injury associates with an earlier onset in sporadic frontotemporal dementia

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Author: Soppela, Helmi1; Krüger, Johanna2,3,4; Hartikainen, Päivi5;
Organizations: 1Institute of Clinical Medicine, Neurology, University of Eastern Finland, Kuopio, Finland
2Research Unit of Clinical Neuroscience, Neurology, University of Oulu, Oulu, Finland
3MRC, Oulu University Hospital, Oulu, Finland
4Neurocenter, Neurology, Oulu University Hospital, Oulu, Finland
5A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland
6Neuro Center, Neurology, Kuopio University Hospital, Kuopio, Finland
7Neuro Center, Neurology, Helsinki University Hospital, Helsinki, Finland
8Centre for Neurodegenerative Disorders, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy
9Neurology Unit, ASST Spedali Civili Brescia, Brescia, Italy
10Clinical Neurosciences, University of Helsinki, Helsinki, Finland
Format: article
Version: accepted version
Access: open
Online Access: PDF Full Text (PDF, 0.2 MB)
Persistent link:
Language: English
Published: IOS Press, 2023
Publish Date: 2023-10-06


Background: Currently, there are few studies considering possible modifiable risk factors of frontotemporal dementia (FTD).

Objectives: In this retrospective case-control study, we evaluated whether a history of traumatic brain injury (TBI) associates with a diagnosis of FTD or modulates the clinical phenotype or onset age in FTD patients.

Methods: We compared the prevalence of prior TBI between individuals with FTD (N = 218) and age and sex-matched AD patients (N = 214) or healthy controls (HC; N = 100). Based on the patient records, an individual was categorized to the TBI+ group if they were reported to have suffered from TBI during lifetime. The possible associations of TBI with age of onset and disease duration were also evaluated in the whole FTD patient group or separately in the sporadic and genetic FTD groups.

Results: The prevalence of previous TBI was the highest in the FTD group (19.3%) when compared to the AD group (13.1%, p = 0.050) or HC group (12%, p = 0.108, not significant). Preceding TBI was more often associated with the sporadic FTD cases than the C9orf72 repeat expansion-carrying FTD cases (p = 0.003). Furthermore, comparison of the TBI+ and TBI- FTD groups indicated that previous TBI was associated with an earlier onset age in the FTD patients (B = 3.066, p = 0.010).

Conclusions: A preceding TBI associates especially with sporadic FTD and with earlier onset of symptoms. The results of this study suggest that TBI may be a triggering factor for the neurodegenerative processes in FTD. However, understanding the precise underlying mechanisms still needs further studies.

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Series: Journal of Alzheimer's disease
ISSN: 1387-2877
ISSN-E: 1875-8908
ISSN-L: 1387-2877
Volume: 91
Issue: 1
Pages: 225 - 232
DOI: 10.3233/JAD-220545
Type of Publication: A1 Journal article – refereed
Field of Science: 3124 Neurology and psychiatry
Copyright information: © 2023 IOS Press.