University of Oulu

Hany Ferdinando, Sadegh Moradi, Vesa Korhonen, Vesa Kiviniemi, and Teemu Myllylä "Fractional amplitude of physiological fluctuations of resting state fNIRS in Alzheimer’s disease patient and healthy control", Proc. SPIE 12365, Neural Imaging and Sensing 2023, 1236507 (14 March 2023);

Fractional amplitude of physiological fluctuations of resting state fNIRS in Alzheimer’s disease patient and healthy control

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Author: Ferdinando, Hany1,2; Moradi, Sadegh3; Korhonen, Vesa1,4;
Organizations: 1Research Unit of Health Science and Technology, Faculty of Medicine, University of Oulu, Finland
2Department of Electrical Engineering, Petra Christian University, Indonesia
3Optoeletronics and Measurement Technique Research Unit, University of Oulu, Finland
4Department of Radiology, Oulu University Hospital, Finland
Format: article
Version: accepted version
Access: open
Online Access: PDF Full Text (PDF, 0.2 MB)
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Language: English
Published: SPIE, 2023
Publish Date: 2023-10-09


Functional magnetic resonance imaging (fMRI) is a common medical device to diagnose Alzheimer’s disease (AD), but it is not for all subjects due to its cost and other issues. We investigated the potential of functional near-infrared spectroscopy (fNIRS) to separate AD patients from controls as a pre-screening prior to more thorough examination using fMRI. For this purpose, two-channel fNIRS device with 690 nm and 830 nm, sampled at 10 Hz, was placed on the forehead with 3 cm distance between light source and detector to provide resting state fNIRS signals from both sides of pre-frontal cortex. We applied fractional amplitude of physiological fluctuation (fAPF), modified from fractional amplitude of low frequency fluctuation (fALFF), to oxy-, deoxy-, and total-hemoglobin in very low frequency (0.008‐0.1 Hz), respiratory (0.1‐0.6 Hz), and cardiac (0.6‐5 Hz) bands. A t-test at 0.05 significance level was used to evaluate if the fAPF score from AD patients and healthy controls is significantly different. We found that fAPF score of total hemoglobin from both side at cardiac band showed its potential to distinguish AD patients from healthy controls. This finding was in-line with the recent finding that heart failure may co-occur in AD patients with the prevalence of one third of cases.

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Series: Progress in biomedical optics and imaging
ISSN: 1605-7422
ISSN-E: 2410-9045
ISSN-L: 1605-7422
ISBN: 978-1-5106-5836-3
ISBN Print: 978-1-5106-5835-6
Volume: 12365
Article number: 1236507
DOI: 10.1117/12.2649864
Host publication: Neural Imaging and Sensing 2023
Conference: Neural Imaging and Sensing
Type of Publication: A4 Article in conference proceedings
Field of Science: 217 Medical engineering
3112 Neurosciences
Copyright information: © (2023) Society of Photo‑Optical Instrumentation Engineers (SPIE). One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this publication for a fee or for commercial purposes, and modification of the contents of the publication are prohibited.