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Turunen, J., Tejesvi, M.V., Paalanne, N. et al. Investigating prenatal and perinatal factors on meconium microbiota: a systematic review and cohort study. Pediatr Res (2023). https://doi.org/10.1038/s41390-023-02783-z

Investigating prenatal and perinatal factors on meconium microbiota : a systematic review and cohort study

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Author: Turunen, Jenni1,2; Tejesvi, Mysore V.2,3; Paalanne, Niko1,4;
Organizations: 1Research Unit of Clinical Medicine, University of Oulu, Oulu, Finland
2Biocenter Oulu, University of Oulu, Oulu, Finland
3Ecology and Genetics, Faculty of Science, University of Oulu, Oulu, Finland
4Department of Pediatrics and Adolescent Medicine, Oulu University Hospital, Oulu, Finland
5Research Service Unit, Oulu University Hospital, Oulu, Finland
6Research Unit of Translational Medicine, University of Oulu, Oulu, Finland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 1.7 MB)
Persistent link: http://urn.fi/urn:nbn:fi-fe20231011139721
Language: English
Published: Springer Nature, 2023
Publish Date: 2023-10-11
Description:

Abstract

Background: The first-pass meconium has been suggested as a proxy for the fetal gut microbiota because it is formed in utero. This systematic review and cohort study investigated how pre- and perinatal factors influence the composition of the meconium microbiota.

Methods: We performed the systematic review using Covidence by searching PubMed, Scopus, and Web of Science databases with the search terms “meconium microbiome” and “meconium microbiota”. In the cohort study, we performed 16 S rRNA gene sequencing on 393 meconium samples and analyzed the sequencing data using QIIME2.

Results: Our systematic review identified 69 studies exploring prenatal factors, immediate perinatal factors, and microbial composition in relation to subsequent health of infants but gave only limited comparative evidence regarding factors related to the composition of the meconium microbiota. The cohort study pointed to a low-biomass microbiota consisting of the phyla Firmicutes, Proteobacteria and Actinobacteriota and the genera Staphylococcus, Escherichia-Shigella and Lactobacillus, and indicated that immediate perinatal factors affected the composition of the meconium microbiota more than did prenatal factors.

Conclusions: This finding supports the idea that the meconium microbiota mostly starts developing during delivery.

Impact:

● It is unclear when the first-pass meconium microbiota develops, and what are the sources of the colonization.

● In this systematic review, we found 69 studies exploring prenatal factors, immediate perinatal factors, and microbial composition relative to subsequent health of infants, but there was no consensus on the factors affecting the meconium microbiota development.

● In this cohort study, immediate perinatal factors markedly affected the meconium microbiota development while prenatal factors had little effect on it.

● As the meconium microbiota composition was influenced by immediate perinatal factors, the present study supports the idea that the initial gut microbiota develops mainly during delivery.

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Series: Pediatric research
ISSN: 0031-3998
ISSN-E: 1530-0447
ISSN-L: 0031-3998
Issue: Early access
DOI: 10.1038/s41390-023-02783-z
OADOI: https://oadoi.org/10.1038/s41390-023-02783-z
Type of Publication: A1 Journal article – refereed
Field of Science: 3123 Gynaecology and paediatrics
Subjects:
Article
Funding: T.T. would like to thank the Academy of Finland for a Clinical Research grant in 2018–2022 and the Pediatric Research Foundation for a grant in 2019–2022. M.V.T. thanks the Päivikki and Sakari Sohlberg Foundation for grants. J.T. would like to thank The Alma and K. A. Snellman Foundation, Oulu, Finland, for a grant in 2023.
Copyright information: © The Author(s) 2023. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
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