|
|
Cold-stimulated brown adipose tissue activation is related to changes in serum metabolites relevant to NAD⁺ metabolism in humans |
|---|---|
| Author: | U-Din, Mueez1,2; de Mello, Vanessa D.3; Tuomainen, Marjo3; |
| Organizations: |
1Turku PET Centre, Turku University Hospital, Turku, Finland 2Turku PET Centre, University of Turku, Turku, Finland 3Department of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland
4Department of Surgery, Turku University Hospital, Turku, Finland
5Chair for Molecular Nutritional Medicine, Technical University of Munich, Freising, Germany 6EKFZ – Else Kröner Fresenius Center for Nutritional Medicine, Technical University of Munich, Freising, Germany 7ZIEL – Institute for Food & Health, Technical University of Munich, Freising, Germany 8Université Côte d'Azur, CNRS, Inserm, iBV, Nice, France 9Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, 00290 Helsinki, Finland 10Research Program for Stem Cells and Metabolism, Faculty of Medicine, University of Helsinki, 00290 Helsinki, Finland 11Department of Pharmacy, University of Eastern Finland, Kuopio, Finland 12Department of Biology, University of Copenhagen, Copenhagen, Denmark 13Obesity and Metabolism Research Unit, USDA-ARS Western Human Nutrition Research Center, Davis, CA, USA 14West Coast Metabolomics Center, Davis Genome Center, University of California, Davis, Davis, CA 95616, USA 15Department of Nutrition, University of California, Davis, Davis, CA 95616, USA 16Obesity Research Unit, Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland 17Obesity Center, Abdominal Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland 18Department of Endocrinology and Clinical Nutrition, Department of Medicine, Kuopio University Hospital, Kuopio, Finland 19Department of Endocrinology, Turku University Hospital, Turku, Finland 20Research Unit for Internal Medicine, Faculty of Medicine, University of Oulu, 90220 Oulu, Finland 21Department of Life Technologies, Food Chemistry and Food Development Unit, University of Turku, Turku, Finland 22Department of Biology and Biological Engineering, Division of Food and Nutrition Science, Chalmers University of Technology, Gothenburg, Sweden |
| Format: | article |
| Version: | published version |
| Access: | open |
| Online Access: | PDF Full Text (PDF, 6.2 MB) |
| Persistent link: | http://urn.fi/urn:nbn:fi-fe20231017140441 |
| Language: | English |
| Published: |
Elsevier,
2023
|
| Publish Date: | 2023-10-17 |
| Description: |
SummaryCold-induced brown adipose tissue (BAT) activation is considered to improve metabolic health. In murine BAT, cold increases the fundamental molecule for mitochondrial function, nicotinamide adenine dinucleotide (NAD⁺), but limited knowledge of NAD⁺ metabolism during cold in human BAT metabolism exists. We show that cold increases the serum metabolites of the NAD⁺ salvage pathway (nicotinamide and 1-methylnicotinamide) in humans. Additionally, individuals with cold-stimulated BAT activation have decreased levels of metabolites from the de novo NAD⁺ biosynthesis pathway (tryptophan, kynurenine). Serum nicotinamide correlates positively with cold-stimulated BAT activation, whereas tryptophan and kynurenine correlate negatively. Furthermore, the expression of genes involved in NAD⁺ biosynthesis in BAT is related to markers of metabolic health. Our data indicate that cold increases serum tryptophan conversion to nicotinamide to be further utilized by BAT. We conclude that NAD⁺ metabolism is activated upon cold in humans and is probably regulated in a coordinated fashion by several tissues. see all
|
| Series: |
Cell reports |
| ISSN: | 2211-1247 |
| ISSN-E: | 2211-1247 |
| ISSN-L: | 2211-1247 |
| Volume: | 42 |
| Issue: | 9 |
| Article number: | 113131 |
| DOI: | 10.1016/j.celrep.2023.113131 |
| OADOI: | https://oadoi.org/10.1016/j.celrep.2023.113131 |
| Type of Publication: |
A1 Journal article – refereed |
| Field of Science: |
3111 Biomedicine |
| Subjects: | |
| Funding: |
The study was financially supported by Academy of Finland (grant numbers 259926, 265204, 269977, 272376, 292839, 314383, 314455, 314456, 321716, 335446, 335443, 335445, profi6 336449, 356733, 404030), the Paulo Foundation, the Finnish Cultural Foundation Southwest Finland Regional and Central Funds, the Turku University Hospital Research Funds, the European Union (EUFP7 project 278373; DIABAT) and a joint French/German grant ANR/DFG (Nutribrite), the Finnish Medical Foundation, Gyllenberg Foundation, Novo Nordisk Foundation (grant numbers NNF20OC0060547, NNF17OC0027232, NNF10OC1013354), the Finnish Diabetes Research Foundation, University of Helsinki and Helsinki University Hospital, Government Research Funds, Finnish-Norwegian Medical Research Foundation, Juhani Aho Foundation for Medical Research, Jalmari ja Rauha Ahokkaan Säätiö, Suorsa Foundation, the NIH West Coast Metabolomics Center 5U24DK097154-04, and USDA CRIS Projects 2032-51530-022-00D and 2032-51530-025-00D (J.W.N.). T.F. and M.K. are funded by the German Research Foundation (BATenergy TRR333/1, Deutsche Forschungsgemeinschaft). N.G. and E.-Z.A. are funded by CNRS, Inserm, and UCA. The USDA is an equal opportunity employer and provider. The study was conducted within the Finnish Center of Excellence in Cardiovascular and Metabolic Diseases supported by the Academy of Finland, University of Turku, Turku University Hospital, and Abo Akademi University. |
| Copyright information: |
© 2023 The Author(s). This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
|
https://creativecommons.org/licenses/by-nc-nd/4.0/ |