The global, regional, and national burden of adult lip, oral, and pharyngeal cancer in 204 countries and territories : a systematic analysis for the global burden of disease study 2019 |
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Author: | da Cunha, Amanda Ramos1; Compton, Kelly2; Xu, Rixing2,3; |
Organizations: |
1Univ Sao Paulo, Sch Publ Hlth, 715 Doutor Arnaldo Ave, BR-01246904 Sao Paulo, SP, Brazil. 2Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98195 USA. 3Sage Bionetworks, Dept Data & Tooling, Seattle, WA USA.
4Univ Washington, Sch Dent, Dept Oral Med, Seattle, WA 98195 USA.
5Univ Washington, Sch Dent, Oral Med Clin, Seattle, WA 98195 USA. 6NYU, Coll Dent, Dept Oral & Maxillofacial Pathol Radiol & Med, New York, NY USA. 7Univ Calif Berkeley, Dept Math, Berkeley, CA 94720 USA. 8Boston Univ, Sch Publ Hlth, Dept Global Hlth, Boston, MA USA. 9Cleveland Clin, Pathol & Lab Med Inst, Cleveland, OH 44106 USA. 10Tanta Univ, Dept Trop Med, Fac Med, Tanta, Egypt. 11Univ Setif Algeria, Dept Med, Setif, Algeria. 12Yasuj Univ Med Sci, Lab Technol Sci Dept, Yasuj, Iran. 13Univ Texas Houston, Dept Plast Surg, Houston, TX USA. 14Univ Human Dev, Dept Banking & Finance, Sulaymaniyah, Iraq. 15Univ Sharjah, Dept Clin Sci, Sharjah, U Arab Emirates. 16Univ Groningen, Dept Clin & Psychosocial Epidemiol, Groningen, Netherlands. 17Univ New South Wales, Ctr Social Res Hlth, Sydney, NSW, Australia. 18Canc Inst NSW, Qual & Syst Performance Unit, Sydney, NSW, Australia. 19Shaqra Univ, Dept Med Biochem, Shaqra, Saudi Arabia. 20Abasyn Univ, Dept Hlth & Biol Sci, Peshawar, Pakistan. 21Univ Kurdistan Hewler, Dept Comp Sci & Engn, Erbil, Iraq. 22Univ South Carolina, Arnold Sch Publ Hlth, Dept Epidemiol & Biostat, Columbia, SC 29208 USA. 23Hamad Med Corp, Geriatr & Long Term Care Dept, Doha, Qatar. 24Hamad Med Corp, Rumailah Hosp, Doha, Qatar. 25Mayo Clin, Fdn Med Educ & Res, Evidence Based Practice Ctr Program, Rochester, MN USA. 26Baqiyatallah Univ Med Sci, Hlth Res Ctr, Tehran, Iran. 27Iran Univ Med Sci, Hlth Management & Econ Res Ctr, Tehran, Iran. 28Iran Univ Med Sci, Dept Hlth Econ, Tehran, Iran. 29Qatar Univ, Coll Dent Med, Doha, Qatar. 30Dortmund Clin, Dortmund, Germany. 31Zahedan Univ Med Sci, Dept Epidemiol & Biostat, Zahedan, Iran. 32Gadjah Mada Univ, Dept Surg, Fac Med, Yogyakarta, Indonesia. 33Charles Sturt Univ, Sch Dent & Med Sci, Orange, NSW, Australia. 34Univ Washington, Coll Arts & Sci, Dept Appl Math, Seattle, WA 98195 USA. 35Univ Washington, Sch Med, Dept Hlth Metr Sci, Seattle, WA USA. 36Univ Cape Town, Dept Mol & Cell Biol, Cape Town, South Africa. 37Univ Lahore, Univ Inst Radiol Sci & Med Imaging Technol, Lahore, Pakistan. 38Zanjan Univ Med Sci, Dept Immunol, Zanjan, Iran. 39Justus Liebig Univ Giessen, Dept Oral & Maxillofacial Surg, Giessen, Germany. 40Univ Tehran Med Sci, NonCommunicable Dis Res Ctr, Tehran, Iran. 41Shahid Beheshti Univ Med Sci, Social Determinants Hlth Res Ctr, Tehran, Iran. 42Gomal Univ, Gomal Ctr Biochem & Biotechnol, Dera Ismail Khan, Pakistan. 43Saveh Univ Med Sci, Dept Nursing, Saveh, Iran. 44Med Univ Lodz, Dept Hypertens, Lodz, Poland. 45Polish Mothers Mem Hosp Res Inst, Lodz, Poland. 46Natl Inst Cholera & Enter Dis, Dept Mol Microbiol & Bacteriol, Kolkata, India. 47Indian Council Med Res, Dept Mol Microbiol, New Delhi, India. 48Univ Bristol, Sch Oral & Dent Sci, Bristol, Avon, England. 49Shiraz Univ Med Sci, Hlth Informat Management, Shiraz, Iran. 50NYU, Coll Dent, Dept Epidemiol & Hlth Promot, New York, NY USA. 51Kings Coll London, Fac Dent Oral & Craniofacial Sci, London, England. 52Govt Inst Forens Sci, Dept Forens Chem, Aurangabad, Maharashtra, India. 53Univ Bahrain, Royal Coll Surg Ireland Med, Dept Anat, Busaiteen, Bahrain. 54Univ Bergen, Dept Global Publ Hlth & Primary Care, Bergen, Norway. 55Canc Registry Norway, Oslo, Norway. 56Univ Ferhat Abbas Setif, Dept Med, Setif, Algeria. 57Univ Hosp Saadna Abdenour, Dept Epidemiol & Prevent Med, Setif, Algeria. 58Univ Florida, Dept Epidemiol, Coll Publ Hlth & Hlth Profess, Gainesville, FL USA. 59Univ Florida, Coll Med, Gainesville, FL USA. 60Univ Florida, Hlth Canc Ctr, Canc Control & Populat Sci Program, Gainesville, FL USA. 61IM Sechenov First Moscow State Med Univ, Dept Epidemiol & Evidence Based Med, Moscow, Russia. 62Univ Med & Pharm Craiova, Dept Clin Pharm, Fac Pharm, Craiova, Romania. 63Inst Canc Res, Prevent & Clin Network, Florence, Italy. 64Univ British Columbia, Sch Populat & Publ Hlth, Fac Med, Vancouver, BC, Canada. 65Datta Meghe Inst Med Sci, Dept Community Med, Sawangi, India. 66Saveetha Inst Med & Tech Sci SIMATS, Saveetha Med Coll & Hosp, Chennai, Tamil Nadu, India. 67King Georges Med Univ, Dept Oral Med & Radiol, Lucknow, Uttar Pradesh, India. 68Univ British Columbia, Dept Oral Biol & Med Sci, Vancouver, BC, Canada. 69Queen Elizabeth Hosp, Dept Clin Oncol, Hong Kong, Peoples R China. 70Vietnam Natl Univ, Int Sch, Ctr Biomed & Community Hlth, Hanoi, Vietnam. 71Fed Med Ctr, Dept Paediat Surg, Umuahia, Nigeria. 72Polytech & Univ Higher Educ Cooperat, Dept Therapeut & Diagnost Technol, Gandra, Portugal. 73Univ Porto, Inst Res & Innovat Hlth, Porto, Portugal. 74Western Norway Univ Appl Sci, Sect Global Hlth & Rehabil, Bergen, Norway. 75Publ Hlth Fdn India, Gurugram, India. 76Indian Council Med Res, New Delhi, India. 77Johns Hopkins Med, Dept Pathol, Baltimore, MD USA. 78Isfahan Univ Med Sci, Dept Pathol, Esfahan, Iran. 79Arak Univ Med Sci, Environm Hlth, Arak, Iran. 80Univ Human Dev, Dept Informat Technol, Sulaymaniyah, Iraq. 81Salale Univ, Sch Publ Hlth, Fiche, Ethiopia. 82Univ Gondar, 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Format: | article |
Version: | published version |
Access: | open |
Online Access: | PDF Full Text (PDF, 8.3 MB) |
Persistent link: | http://urn.fi/urn:nbn:fi-fe20231020140692 |
Language: | English |
Published: |
American Medical Association,
2023
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Publish Date: | 2023-10-20 |
Description: |
AbstractImportance: Lip, oral, and pharyngeal cancers are important contributors to cancer burden worldwide, and a comprehensive evaluation of their burden globally, regionally, and nationally is crucial for effective policy planning. Objective: To analyze the total and risk-attributable burden of lip and oral cavity cancer (LOC) and other pharyngeal cancer (OPC) for 204 countries and territories and by Socio-demographic Index (SDI) using 2019 Global Burden of Diseases, Injuries, and Risk Factors (GBD) Study estimates. Evidence review: The incidence, mortality, and disability-adjusted life years (DALYs) due to LOC and OPC from 1990 to 2019 were estimated using GBD 2019 methods. The GBD 2019 comparative risk assessment framework was used to estimate the proportion of deaths and DALYs for LOC and OPC attributable to smoking, tobacco, and alcohol consumption in 2019. Findings: In 2019, 370 000 (95% uncertainty interval [UI], 338 000–401 000) cases and 199 000 (95% UI, 181 000–217 000) deaths for LOC and 167 000 (95% UI, 153 000‐180 000) cases and 114 000 (95% UI, 103 000–126 000) deaths for OPC were estimated to occur globally, contributing 5.5 million (95% UI, 5.0‐6.0 million) and 3.2 million (95% UI, 2.9‐3.6 million) DALYs, respectively. From 1990 to 2019, low-middle and low SDI regions consistently showed the highest age-standardized mortality rates due to LOC and OPC, while the high SDI strata exhibited age-standardized incidence rates decreasing for LOC and increasing for OPC. Globally in 2019, smoking had the greatest contribution to risk-attributable OPC deaths for both sexes (55.8% [95% UI, 49.2%‐62.0%] of all OPC deaths in male individuals and 17.4% [95% UI, 13.8%‐21.2%] of all OPC deaths in female individuals). Smoking and alcohol both contributed to substantial LOC deaths globally among male individuals (42.3% [95% UI, 35.2%‐48.6%] and 40.2% [95% UI, 33.3%‐46.8%] of all risk-attributable cancer deaths, respectively), while chewing tobacco contributed to the greatest attributable LOC deaths among female individuals (27.6% [95% UI, 21.5%‐33.8%]), driven by high risk-attributable burden in South and Southeast Asia. Conclusions and relevance: In this systematic analysis, disparities in LOC and OPC burden existed across the SDI spectrum, and a considerable percentage of burden was attributable to tobacco and alcohol use. These estimates can contribute to an understanding of the distribution and disparities in LOC and OPC burden globally and support cancer control planning efforts. see all
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Series: |
JAMA oncology |
ISSN: | 2374-2437 |
ISSN-E: | 2374-2445 |
ISSN-L: | 2374-2437 |
Issue: | Early access |
DOI: | 10.1001/jamaoncol.2023.2960 |
OADOI: | https://oadoi.org/10.1001/jamaoncol.2023.2960 |
Type of Publication: |
A1 Journal article – refereed |
Field of Science: |
3122 Cancers 3125 Otorhinolaryngology, ophthalmology |
Subjects: | |
Funding: |
Financial support for Global Burden of Disease research was provided by the Bill & Melinda Gates Foundation. |
Copyright information: |
© 2023 GBD 2019 Lip, Oral, and Pharyngeal Cancer Collaborators. JAMA Oncology. This is an open access article distributed under the terms of the CC-BY License. |
https://creativecommons.org/licenses/by/4.0/ |