University of Oulu

Mattila, T.M., Svensson, E.M., Juras, A. et al. Genetic continuity, isolation, and gene flow in Stone Age Central and Eastern Europe. Commun Biol 6, 793 (2023).

Genetic continuity, isolation, and gene flow in Stone Age Central and Eastern Europe

Saved in:
Author: Mattila, Tiina M.1; Svensson, Emma M.1; Juras, Anna2;
Organizations: 1Human Evolution, Department of Organismal Biology, Uppsala University, 75105, Uppsala, Sweden
2Institute of Human Biology & Evolution, Faculty of Biology, Adam Mickiewicz University in Poznań, 61-614, Poznań, Poland
3Department of Archaeology and Ancient History, Uppsala University, 75126, Uppsala, Sweden
4Geography Research Unit, University of Oulu, 90014, Oulu, Finland
5Kerttu Saalasti Institute, University of Oulu, 90014, Oulu, Finland
6Department of Anthropology and Archaeology, University of Bristol, Bristol, UK
7Institute of Archaeology, University of Gdańsk, 80-851, Gdańsk, Poland
8“Francisc I. Rainer” Institute of Anthropology, Romanian Academy, 050711, Bucharest, Romania
9Faculty of History, University of Bucharest, 030167, Bucharest, Romania
10National History Museum of Transylvania, Cluj-Napoca, Romania
11Vasile Pârvan Institute of Archaeology, Bucharest, Romania
12Institute of Archaeology, Jagiellonian University, 31-007, Kraków, Poland
13Karkonosze Museum, 58-500, Jelenia Góra, Poland
14Polish Academy of Sciences, Institute of Archaeology and Ethnology, 31-016, Kraków, Poland
15Museum of Folk Culture, 11-600, Węgorzewo, Poland
16Faculty of Archaeology, Adam Mickiewicz University in Poznań, 61-614, Poznań, Poland
17Department of Bioarchaeology, Institute of Archaeology, National Academy of Sciences of Ukraine, 04210, Kyiv, Ukraine
18Department of Physical Anthropology, Institute of Forensic Medicine, University of Bern, 3008, Bern, Switzerland
19Archaeological Museum, 61-781, Poznań, Poland
20Institute of Biological Sciences, Cardinal Stefan Wyszyński University in Warsaw, 01-938, Warszawa, Poland
21Centre for Palaeogenetics, Stockholm University and the Swedish Museum of Natural History, 106 91, Stockholm, Sweden
22Department of Archaeology and Classical Studies, Stockholm University, 106 91, Stockholm, Sweden
23Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, 6525, HP, Nijmegen, the Netherlands
24Department for Genomics & Immunoregulation, Life and Medical Sciences Institute (LIMES), University of Bonn, 53115, Bonn, Germany
25Grand Valley State University, Department of Biology, Allendale, MI, 49401, USA
26Museum of Cultural History, University of Oslo, 0130, Oslo, Norway
27Centre for Anthropological Research, University of Johannesburg, Auckland Park, 2006, Johannesburg, South Africa
28SciLifeLab, Uppsala University, 75105, Uppsala, Sweden
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 3.2 MB)
Persistent link:
Language: English
Published: Springer Nature, 2023
Publish Date: 2023-10-24


The genomic landscape of Stone Age Europe was shaped by multiple migratory waves and population replacements, but different regions do not all show similar patterns. To refine our understanding of the population dynamics before and after the dawn of the Neolithic, we generated and analyzed genomic sequence data from human remains of 56 individuals from the Mesolithic, Neolithic, and Eneolithic across Central and Eastern Europe. We found that Mesolithic European populations formed a geographically widespread isolation-by-distance zone ranging from Central Europe to Siberia, which was already established 10,000 years ago. We found contrasting patterns of population continuity during the Neolithic transition: people around the lower Dnipro Valley region, Ukraine, showed continuity over 4000 years, from the Mesolithic to the end of the Neolithic, in contrast to almost all other parts of Europe where population turnover drove this cultural change, including vast areas of Central Europe and around the Danube River.

see all

Series: Communications biology
ISSN: 2399-3642
ISSN-E: 2399-3642
ISSN-L: 2399-3642
Volume: 6
Article number: 793
DOI: 10.1038/s42003-023-05131-3
Type of Publication: A1 Journal article – refereed
Field of Science: 615 History and archaeology
1181 Ecology, evolutionary biology
1171 Geosciences
Funding: This work was funded by the Finnish Cultural Foundation (to T.M.M.), Wenner-Gren Foundations (projects UPD2018-0308 and P2020-0008 to T.M.M. under supervision of M.J.), and by the Knut and Alice Wallenberg Foundation (to M.J., A.G., and J.S.). H.M. was supported by Swedish Research Council grant no. 2017-02503 and by Riksbankens Jubileumsfond grant no. P21-0266. Open access funding provided by Uppsala University.
Copyright information: © The Author(s) 2023. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit