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Efficacy, feasibility and tolerability of ketogenic diet for the treatment of poor response to bariatric surgery |
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| Author: | Vinciguerra, F.1; Longhitano, S.1; Carrubba, N.1; |
| Organizations: |
1Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy 2General and Emergency Surgery Department, Garibaldi Hospital, Catania, Italy 3Endocrinology Unit: Garibaldi Hospital, Catania, Italy
4Rovaniemi Health Center, Rovaniemi and Primary Health Care Unit, Lapland Central Hospital, Rovaniemi, Finland
5Medical Research Center Oulu, University of Oulu and Oulu University Hospital, Oulu, Finland 6Diabetes, Obesity and Dietetic Center, Garibaldi Hospital, Catania, Italy |
| Format: | article |
| Version: | published version |
| Access: | open |
| Online Access: | PDF Full Text (PDF, 0.6 MB) |
| Persistent link: | http://urn.fi/urn:nbn:fi-fe20231030141915 |
| Language: | English |
| Published: |
Springer Nature,
2023
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| Publish Date: | 2023-10-30 |
| Description: |
AbstractPurpose: Poor response to bariatric surgery, namely insufficient weight loss (IWL) or weight regain (WR), is a critical issue in the treatment of obesity. The purpose of our study was to assess the efficacy, feasibility, and tolerability of very low-calorie ketogenic diet (VLCKD) for the management of this condition. Methods: A real-life prospective study was conducted on twenty-two patients who experienced poor response after bariatric surgery and followed a structured VLCKD. Anthropometric parameters, body composition, muscular strength, biochemical analyses, and nutritional behavior questionnaires were evaluated. Results: A significant weight loss (mean 14.1 ± 4.8%), mostly due to fat mass, was observed during VLCKD with the preservation of muscular strength. The weight loss obtained allowed patients with IWL to reach a body weight significantly lower than that obtained at the post-bariatric surgery nadir and to report the body weight of patients with WR at the nadir observed after surgery. The significantly beneficial changes in nutritional behaviors and metabolic profiles were observed without variations in kidney and liver function, vitamins, and iron status. The nutritional regimen was well tolerated, and no significant side effects were detected. Conclusion: Our data demonstrate the efficacy, feasibility, and tolerability of VLCKD in patients with poor response after bariatric surgery. see all
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| Series: |
Journal of endocrinological investigation |
| ISSN: | 0391-4097 |
| ISSN-E: | 1720-8386 |
| ISSN-L: | 0391-4097 |
| Volume: | 46 |
| Issue: | 9 |
| Pages: | 1807 - 1814 |
| DOI: | 10.1007/s40618-023-02034-2 |
| OADOI: | https://oadoi.org/10.1007/s40618-023-02034-2 |
| Type of Publication: |
A1 Journal article – refereed |
| Field of Science: |
3121 General medicine, internal medicine and other clinical medicine 3126 Surgery, anesthesiology, intensive care, radiology |
| Subjects: | |
| Funding: |
Open access funding provided by Università degli Studi di Catania within the CRUI-CARE Agreement. |
| Copyright information: |
© The Author(s) 2023. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
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https://creativecommons.org/licenses/by/4.0/ |