Ville E.J. Sirviö, Jari V. Räsänen, Joonas H. Kauppila, Time trends in mortality of oesophageal cancer in Finland over 30 years, European Journal of Surgical Oncology, Volume 49, Issue 9, 2023, 106905, ISSN 0748-7983, https://doi.org/10.1016/j.ejso.2023.04.004
Time trends in mortality of oesophageal cancer in Finland over 30 years
|Author:||Sirviö, Ville E. J.1; Räsänen, Jari V.1; Kauppila, Joonas H.2,3|
1Department of Oesophageal and General Thoracic Surgery, Helsinki University Hospital and University of Helsinki, Finland
2Upper Gastrointestinal Surgery, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
3Surgery Research Unit, Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland
|Online Access:||PDF Full Text (PDF, 0.7 MB)|
|Persistent link:|| http://urn.fi/urn:nbn:fi-fe20231103142883
|Publish Date:|| 2023-11-03
Introduction: Oesophageal cancer survival is reported by epidemiological studies, but knowledge on survival trends regarding different histologies and operative treatment status is lacking.
Materials and methods: Data from all patients diagnosed with oesophageal cancer in Finland in 1987–2016 was collected from national registries. 1-, 3- and 5-year survival rates were examined stratified by histology (adenocarcinoma (OAC) and squamous cell carcinoma (OSCC)) and treatment strategy (surgery, no surgery). Hazard ratios (HR) with 95% confidence intervals (CI) for death were provided by multivariable Cox regression, adjusted for confounders.
Results: Of the 9102 patients, 3140 had OAC (1074 [34%] oesophagectomies), and 3778 had OSCC (870 [23%] oesophagectomies). Men were overrepresented in both OAC (77%) and OSCC (55%). The proportion of oesophagectomies decreased in both histologies. From 1987 to 1991 to 2012–2016, 5-year survival increased from 11% to 22% in OAC and from 7% to 13% in OSCC. For patients undergoing oesophagectomy, the corresponding increases were from 20% to 49% in OAC and from 11% to 54% in OSCC, and non-operated patients from 5% to 8% and from 5% to 7%, respectively. Earlier calendar period, older age and comorbidity were associated with mortality in both histologies. Female sex was a protective factor for patients operated for OSCC (HR 1.56 (95% CI 1.33–1.83), men versus women).
Conclusions: The prognosis of oesophageal cancer has improved in Finland over the last 30 years in both main histological types. The survival of patients undergoing oesophagectomy has drastically improved, while the prognosis of patients not undergoing surgery is slowly improving but remains poor.
European journal of surgical oncology
|Type of Publication:||
A1 Journal article – refereed
|Field of Science:||
This work is supported by research grants from the Sigrid Jusélius Foundation (Sigrid Juséliuksen Säätiö), The Finnish Cancer Foundation (Syöpäsäätiö), Päivikki and Sakari Sohlberg Foundation and Orion Research Foundation (Orionin tutkimussäätiö). The sources of funding did not have a role in any part of this research, including study design, data acquisition, data analysis and interpretation, manuscript preparation and submission for publication.
/© 2023 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).