University of Oulu

Elisa Paavilainen, Harri Niinikoski, Riitta Parkkola, Kalle Koskensalo, Hilkka Nikkinen, Riitta Veijola, Marja Vääräsmäki, Britt-Marie Loo, Päivi Tossavainen, Tapani Rönnemaa, Kristiina Tertti, Metformin versus insulin for gestational diabetes: Adiposity variables and adipocytokines in offspring at age of 9 years, Diabetes Research and Clinical Practice, Volume 202, 2023, 110780, ISSN 0168-8227, https://doi.org/10.1016/j.diabres.2023.110780

Metformin versus insulin for gestational diabetes : adiposity variables and adipocytokines in offspring at age of 9 years

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Author: Paavilainen, Elisa1; Niinikoski, Harri1; Parkkola, Riitta2;
Organizations: 1Department of Pediatrics and Adolescent Medicine, University of Turku and Turku University Hospital, Turku, Finland
2Department of Radiology, University of Turku and Turku University Hospital, Turku, Finland
3Department of Medical Physics, Turku University Hospital, Turku, Finland
4Department of Obstetrics and Gynecology, Research Unit of Clinical Medicine, University of Oulu and Oulu University Hospital, Oulu, Finland
5Department of Pediatrics, Research Unit of Clinical Medicine, Medical Research Center, University of Oulu and Oulu University Hospital, Oulu, Finland
6Joint Clinical Biochemistry Laboratory of University of Turku and Turku University Hospital, Turku, Finland
7Department of Medicine, University of Turku and Division of Medicine, Turku University Hospital, Turku, Finland
8Department of Obstetrics and Gynecology, University of Turku and Turku University Hospital, Turku, Finland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 2.5 MB)
Persistent link: http://urn.fi/urn:nbn:fi-fe20231107143420
Language: English
Published: Elsevier, 2023
Publish Date: 2023-11-07
Description:

Abstract

Aims: To compare body composition, visceral adiposity, adipocytokines, and low-grade inflammation markers in prepubertal offspring of mothers who were treated with metformin or insulin for gestational diabetes mellitus (GDM).

Methods: 172 offspring of 311 mothers randomized to receive metformin (n = 82) or insulin (n = 90) for GDM were studied at 9 years of age (follow-up rate 55%). Measurements included anthropometrics, adipocytokines, markers of the low-grade inflammation, abdominal magnetic resonance imaging (MRI), magnetic liver spectrometry (MRS), and whole body dual-energy X-ray absorptiometry (DXA).

Results: Serum markers of low-grade inflammation, visceral adipose tissue volume, total fat percentage, and liver fat percentage were similar between the study groups. Serum adiponectin concentration was higher in children in the metformin group compared to insulin group (median 10.37 vs 9.50 µg/ml, p = 0.016). This difference between groups was observed in boys only (median 12.13 vs 7.50 µg/ml, p < 0.001). Leptin/adiponectin-ratio was lower in boys in the metformin group than in the insulin group (median 0.30 vs 0.75; p = 0.016).

Conclusions: Maternal metformin treatment for GDM had no effects on adiposity, body composition, liver fat, or inflammation markers in prepubertal offspring compared to maternal insulin treatment but was associated with higher adiponectin concentration and lower leptin/adiponectin-ratio in boys.

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Series: Diabetes research and clinical practice
ISSN: 0168-8227
ISSN-E: 1872-8227
ISSN-L: 0168-8227
Volume: 202
Article number: 110780
DOI: 10.1016/j.diabres.2023.110780
OADOI: https://oadoi.org/10.1016/j.diabres.2023.110780
Type of Publication: A1 Journal article – refereed
Field of Science: 3121 General medicine, internal medicine and other clinical medicine
3123 Gynaecology and paediatrics
Subjects:
Funding: This study was financially supported by the Diabetes Research Foundation, Finland; the Finnish Foundation for Paediatric Research; Special Governmental Grants for Health Sciences (Turku University Hospital and Oulu University Hospital, Finland); Yrjö Jahnsson Foundation, Finland and the Turku University Hospital Research Foundation, Finland.
Copyright information: © 2023 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
  https://creativecommons.org/licenses/by/4.0/