University of Oulu

Hakkola, M., Vehviläinen, P., Muotka, J., Tejesvi, M.V., Pokka, T., Vähäsarja, P., Hanni, A.-M., Renko, M., Uhari, M., Salo, J. and Tapiainen, T. (2023), Cranberry-lingonberry juice affects the gut and urinary microbiome in children - a randomized controlled trial. APMIS, 131: 112-124.

Cranberry-lingonberry juice affects the gut and urinary microbiome in children : a randomized controlled trial

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Author: Hakkola, Mikael1; Vehviläinen, Pekka2; Muotka, Janita1;
Organizations: 1Research Unit of Clinical Medicine and Medical Research Centre Oulu, University of Oulu, Oulu, Finland
2Ecology and Genetics, Faculty of Science, University of Oulu, Oulu, Finland
3Department of Pediatrics and Adolescent Medicine, Oulu University Hospital, Oulu, Finland
4Oulu Health Care Center, Oulu, Finland
5University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland
6Biocenter Oulu, University of Oulu, Oulu, Finland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 3.8 MB)
Persistent link:
Language: English
Published: John Wiley & Sons, 2023
Publish Date: 2023-11-07


The mechanism by which cranberry-lingonberry juice (CLJ) prevents urinary tract infections (UTI) in children remains unknown. We hypothesized that it alters the composition of the gut or urinary microbiome. Altogether, 113 children with UTIs were randomly allocated to drink either CLJ or a placebo juice for 6 months. We collected urinary samples at 3 months and fecal samples at 3, 6 and 12 months and used next-generation sequencing of the bacterial 16S gene. The children who consumed CLJ had a lower abundance of Proteobacteria (p = 0.03) and a higher abundance of Firmicutes phylum (p = 0.04) in their urinary microbiome at 3 months than did those in the placebo group. The abundance of Escherichia coli in the urinary microbiome was 6% in the CLJ group and 13% in the placebo group (p = 0.42). In the gut microbiome the abundance of Actinobacteria at 3 and 12 months was higher in the children receiving CLJ. The diversity of the urinary and gut microbiome did not differ between the groups. The children drinking CLJ had a different urinary and gut microbiome from those receiving a placebo juice. A healthy urinary microbiome may be important in preventing UTIs in children.

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Series: APMIS
ISSN: 0903-4641
ISSN-E: 1600-0463
ISSN-L: 0903-4641
Volume: 131
Issue: 3
Pages: 112 - 124
DOI: 10.1111/apm.13292
Type of Publication: A1 Journal article – refereed
Field of Science: 3123 Gynaecology and paediatrics
Funding: The authors thank the Finnish Medical Foundation (Mikael Hakkola), Päivikki and Sakari Sohlberg Foundation (Mysore Tejesvi), Finnish Pediatric Research Foundation (Terhi Tapiainen), Juho Vainio Foundation (Terhi Tapiainen), Stiftelsen Alma och KA Snellman Foundation (Terhi Tapiainen) and Academy of Finland, Clinical Researcher (Terhi Tapiainen) for funding this study.
Copyright information: © 2023 The Authors. APMIS published by John Wiley & Sons Ltd on behalf of Scandinavian Societies for Pathology, Medical Microbiology and Immunology. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.