University of Oulu

Mustaniemi, S., Keikkala, E., Kajantie, E. et al. Serum ceramides in early pregnancy as predictors of gestational diabetes. Sci Rep 13, 13274 (2023).

Serum ceramides in early pregnancy as predictors of gestational diabetes

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Author: Mustaniemi, Sanna1,2; Keikkala, Elina1,2; Kajantie, Eero1,2,3,4;
Organizations: 1Clinical Medicine Research Unit, Medical Research Center Oulu, Oulu University Hospital and University of Oulu, PL 23, 90029 Oulu, Finland
2Population Health Unit, Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Oulu, Finland
3Children’s Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
4Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway
5Zora Biosciences Oy, Espoo, Finland
6Biobank Borealis of Northern Finland, Oulu University Hospital, Oulu, Finland
7Faculty of Medicine, University of Oulu, Oulu, Finland
8Nordlab, Oulu, Finland
9Department of Obstetrics and Gynecology, Center for Child, Adolescence and Maternal Health, Tampere University Hospital and Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland
10Medical and Clinical Genetics, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
11Institute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland
12Department of General Practice and Primary Health Care, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
13Folkhälsan Research Center, Helsinki, Finland
14Department of Obstetrics and Gynecology and Human Potential Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
15Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology, and Research, Singapore, Singapore
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 1.7 MB)
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Language: English
Published: Springer Nature, 2023
Publish Date: 2023-11-07


Ceramides contribute to the development of type 2 diabetes but it is uncertain whether they predict gestational diabetes (GDM). In this multicentre case–control study including 1040 women with GDM and 958 non-diabetic controls, early pregnancy (mean 10.7 gestational weeks) concentrations of four ceramides—Cer(d18:1/16:0), Cer(d18:1/18:0), Cer(d18:1/24:0) and Cer(d18:1/24:1)—were determined by a validated mass-spectrometric method from biobanked serum samples. Traditional lipids including total cholesterol, LDL, HDL and triglycerides were measured. Logistic and linear regression and the LASSO logistic regression were used to analyse lipids and clinical risk factors in the prediction of GDM. The concentrations of four targeted ceramides and total cholesterol, LDL and triglycerides were higher and HDL was lower among women with subsequent GDM than among controls. After adjustments, Cer(d18:1/24:0), triglycerides and LDL were independent predictors of GDM, women in their highest quartile had 1.44-fold (95% CI 1.07–1.95), 2.17-fold (95% CI 1.57–3.00) and 1.63-fold (95% CI 1.19–2.24) odds for GDM when compared to their lowest quartiles, respectively. In the LASSO regression modelling ceramides did not appear to markedly improve the predictive performance for GDM alongside with clinical risk factors and triglycerides. However, their adverse alterations highlight the extent of metabolic disturbances involved in GDM.

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Series: Scientific reports
ISSN: 2045-2322
ISSN-E: 2045-2322
ISSN-L: 2045-2322
Volume: 13
Issue: 1
Article number: 13274
DOI: 10.1038/s41598-023-40224-3
Type of Publication: A1 Journal article – refereed
Field of Science: 3123 Gynaecology and paediatrics
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