University of Oulu

Prostatasyövän ulkoisen sädehoidon kohdennus

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Author: Karppinen, Iina1
Organizations: 1University of Oulu, Faculty of Medicine, Health Sciences
Format: ebook
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 1 MB)
Persistent link: http://urn.fi/URN:NBN:fi:oulu-201805161817
Language: Finnish
Published: Oulu : I. Karppinen, 2018
Publish Date: 2018-05-18
Physical Description: 36 p.
Thesis type: Bachelor's thesis
Description:

Tiivistelmä

Työssä tarkoituksena on tutkia prostatasyövän hoidossa prostataan asetettavien radiolähettimien antamaa paikannustietoa suhteessa kartiokeilakuviin sädehoidon lineaarikiihdyttimellä.

Työ toteutetaan ottamalla ensin 3D-mallista, johon radiolähettimet asetetaan, referenssikuvat tietokonetomografialla, joihin sitten verrataan sekä Calypsolla saatavaa paikannustietoa että kartiokeilakuvien antamaa informaatiota paikasta. 3D-malliin eli fantomiin suunnitellaan kolme erilaista lähettimien asettelua ja kuvaustilanteita muunnellaan sekä ilman kallistusta että 2° ja 8° asteen kallistuksilla. Eri menetelmin saatavaa paikannustietoa vertailemalla pyritään saamaan parempi käsitys siitä, onko Calypsolla tapahtuva paikannus luotettavaa verrattuna kartiokeilakuviin.

Mittauksien perusteella Calypson asettelutarkkuudeksi x,y,z -koordinaatistossa saatiin 1,1mm ± 0,9mm, jolloin suurin mahdollinen virhe on 2mm. Suurimmaksi mahdolliseksi poikkeamaksi osoittautui 1,5mm±0,9mm.

Calypsolla saavutettiin vertailukelpoinen tulos kartiokeilatomografiaan nähden. Reaaliaikainen tuumorin paikannus ja sädehoidon kohdennus Calypson avulla lisää hoidon tehokkuutta ja turvallisuutta, sillä tuumorin liikettä kyetään seuraamaan hoidon aikana.

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Abstract

The aim of this study was to explore the association between endurance athletes’ heart rate measured during night sleep and in the morning at rest.

Two techniques were used to measure heart rate. Night-time heart rate was measured from the wrist using optical photoplethysmography and resting heart rate was measured using a chest strap sensor and electrocardiography. Correlation coefficient and p-value were used to determine the association between heart rate measured during night sleep and in the morning at rest at the individual level. At the group level, paired samples t-test was used to compare the averages of heart rate values and Bland Altman -plot to visualize the difference between measuring methods.

A positive correlation was found between the heart rate measured during night sleep and in the morning at rest, but five examinees did not have a significant correlation coefficient. The measures of 12 examinees indicated statistically significant correlation, and the correlation coefficients varied in the range 0.31–0.71. There were six weak correlations (0.2–0.4), four moderate correlations (0.4–0.6) and two high correlations (0.6–0.8) in the results. High correlations were significant. Statistically significant difference (p=0.001) between the measuring methods was found at the group level. Bland Altman -method indicates the variation between the heart rate values as the night-time heart rate was 3 bpm higher than the resting heart rate on average.

Correlation coefficients calculated from heart rate measurements were very individual, and therefore the dependency between night-time heart rate and resting heart rate measured in the morning cannot be generalized to a population.

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Copyright information: © Iina Karppinen, 2018. This publication is copyrighted. You may download, display and print it for your own personal use. Commercial use is prohibited.