University of Oulu

The association of PCOS and hypertensive disorders of pregnancy : a community based approach

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Author: Rantakallio, Juhani1
Organizations: 1University of Oulu, Faculty of Medicine, Medicine
Format: ebook
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 1.8 MB)
Pages: 27
Persistent link: http://urn.fi/URN:NBN:fi:oulu-202002181155
Language: English
Published: Oulu : J. Rantakallio, 2020
Publish Date: 2021-11-23
Thesis type: Other thesis
Thesis subtype: Käsikirjoitus
Tutor: Morin-Papunen, Laure
Reviewer: Morin-Papunen, Laure
Vääräsmäki, Marja
Description:

Abstract

Objective. To investigate the prevalence of hypertensive disorders of pregnancy (HDP), and the respective roles of PCOS, obesity, lifelong weight gain (WG) and hyperandrogenemia in the disease development by age 46.

Methods. The Northern Finland Birth Cohort 1966, with follow-up at ages 14, 31 and 46, including women with (n=408) and without (n=3373) HDP diagnosis. HDP diagnosis was combined from the questionnaire data at age 46, hospital discharge records and Finnish Medical Birth Registers. Women with both oligo-amenorrhea and hirsutism at age 31 or with PCOS diagnosis by age 46 (n=279) were compared with the women without PCOS (n=1577).

Results. Women with PCOS had an increased HDP risk (odds ratio [OR]=1.56 [95%CI:1.03–2.37]), but the association disappeared after adjusting for BMI at age 31. The risk for HDP was not increased among normal weight PCOS women. The increase of BMI (kg/m²) from age 14 to 31 was significantly greater in both PCOS (median (interquartile range): 5.94(3.69;11.1), p<0.001) and non-PCOS (4.89(3.21;7.57), p<0.001) women with HDP and also in PCOS women without HDP (4.59(2.40;7.54), p=0.009) compared to non-PCOS without HDP. Among women with PCOS, BMI increase was greater in women with than without HDP (5.94(3.69;11.1) vs 4.59(2.40;7.54), p=0.015). Hyperandrogenemia at ages 31 or 46 did not associate with HDP (OR=1.44 [95%CI: 0.98–2.11]).

Conclusion: Obesity and weight gain from adolescence to age 46, but not PCOS per se or hyperandrogenemia, were associated with an increased risk of HDP. There was a strong synergistic association of PCOS and obesity regarding HDP risk.

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Huomautus

Opinnäytteenä käsikirjoitus, preprint: Rantakallio, J., Nevalainen, J., West, S., Ollila, M.-M., Puukka, K., Bloigu, A., Järvelin, M.-R., Tapanainen, J. S., Franks, S., Piltonen, T. T., Vääräsmäki, M., & Morin-Papunen, L. (2020). The association of PCOS and hypertensive disorders of pregnancy -a community based approach. Authorea. https://doi.org/10.22541/au.158575928.83624745

https://doi.org/10.22541/au.158575928.83624745

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Notice

The thesis is manuscript, preprint: Rantakallio, J., Nevalainen, J., West, S., Ollila, M.-M., Puukka, K., Bloigu, A., Järvelin, M.-R., Tapanainen, J. S., Franks, S., Piltonen, T. T., Vääräsmäki, M., & Morin-Papunen, L. (2020). The association of PCOS and hypertensive disorders of pregnancy -a community based approach. Authorea. https://doi.org/10.22541/au.158575928.83624745

https://doi.org/10.22541/au.158575928.83624745

see all

Subjects:
Copyright information: © Juhani Rantakallio, 2020. This publication is copyrighted. You may download, display and print it for your own personal use. Commercial use is prohibited.