University of Oulu

INFRAFRONTIER-I3 - Development of mouse mutant resources for functional analyses of human diseases - Enhancing the translation of research into innovation (312325)

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Description:
The mouse shows great similarities in development, physiology and biochemistry to humans, which makes it a key model for research into human disease. The major challenges for mouse functional genomics in the 21st century are to: • Develop a series of mutant alleles for every gene in the mouse genome • Determine the phenotypic consequences of each mutation • Identify mouse models for the complete disease spectrum in humans To further develop and exploit the emerging mouse mutant resource, mouse models must be preserved and made available to the European biomedical research community. To this effect, the Infrafrontier-I3 project brings together the leading European centers for systemic phenotyping of mouse mutants and the European Mouse Mutant Archive network. The Infafrontier-I3 partners aim to meet the future challenges presented by phenotyping, archiving and disseminating mouse models in the ERA as follows: • Contribute to resource development by archiving of 1215 new mouse mutant lines • Provide free of charge Transnational Access to mouse production and 1st line phenotyping capacities • Offer a specialized axenic service to produce, maintain and to distribute germ-free mice • Provide user friendly accession of Infrafrontier services, extensive manual data curation and cross referencing with other mouse database • Improve user services by developing novel phenotyping and cryopreservation SOPs and by refining innovative research instrumentation • Engage with the user community using a wide range of PR activities, a dedicated user meeting and an industry liaison workshop • Offer state of the art cryopreservation and phenotyping training courses • Benchmark Infrafrontier services with other major repositories The comprehensive physical and data resources that will be generated by Infrafrontier-I3 will contribute to link basic biomedical research to medical applications and thereby drive innovation and support the Europe 2020 Strategy.
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Grant Number: 312325
Cordis Record Number: 106249
Project Start Date: 2013-01-01
Project End Date: 2016-12-31
Project Funder: EC/FP7/SP4/INFRA
EC Special Clause: false
Datapilot: false
Open Access Mandate: false
Coordinator: HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
Coordinator contact: Ertel, Jürgen
Coordinator EU Contribution: 1879671.36
EU Max Contribution: 9900000
Total Cost: 12431663.54
Participant: BIOMEDICAL SCIENCES RESEARCH CENTER ALEXANDER FLEMING
Toronto Centre for Phenogenomics Inc.
EUROPEAN MOLECULAR BIOLOGY LABORATORY
FUNDACAO CALOUSTE GULBENKIAN
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS
AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS
TSE SYSTEMS GMBH
KOBENHAVNS UNIVERSITET
MEDICAL RESEARCH COUNCIL
HELMHOLTZ-ZENTRUM FUER INFEKTIONSFORSCHUNG GMBH
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
CENTRE EUROPEEN DE RECHERCHE EN BIOLOGIE ET MEDECINE
CONSIGLIO NAZIONALE DELLE RICERCHE
INFRAFRONTIER GMBH
TEL AVIV UNIVERSITY
OULUN YLIOPISTO
KAROLINSKA INSTITUTET
VETERINAERMEDIZINISCHE UNIVERSITAET WIEN
UNIVERSITAT AUTONOMA DE BARCELONA
USTAV MOLEKULARNI GENETIKY AKADEMIE VED CESKE REPUBLIKY VEREJNA VYZKUMNA INSTITUCE
GENOME RESEARCH LIMITED
KATHOLIEKE UNIVERSITEIT LEUVEN
More information: Detailed project information (CORDIS)
Detailed project information (Openaire)
Copyright information: © European Union, 1994-2017 CORDIS, http://cordis.europa.eu/
All materials created by the OpenAIRE consortium are licensed under a Creative Commons Attribution 4.0 International License
  http://cordis.europa.eu/
https://creativecommons.org/licenses/by/4.0/